Calcium signaling and nucleotide metabolism
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Scope of this subject
This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.
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Research vocabulary
cyclic ADP-ribose; NAADP; TRPML1; ADP-ribosyl cyclase; two-pore channels; TPC2; TPC1; mucolipidosis type IV; lysosomal calcium release; MCOLN1; lysosomal ion channels; NAADP receptor; TRPML3; TRPML2; lysosomal calcium; PI(3,5)P2; NAD+ metabolites; TRPML
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Numeric address and provenance
Morton address: 38293808298863307 · morton4x16-v1
Coordinates: (1, 13, 1314, 13415). The address interleaves categorical identifier bits. Nearby addresses are not guaranteed to describe semantically similar subjects.
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