{"cited_by_count":215493,"description":"This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.","display_name":"Calcium signaling and nucleotide metabolism","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13415","wikipedia":"https://en.wikipedia.org/wiki/Lysosomal_calcium_signaling"},"field_id":"13","id":"T13415","keywords":[{"display_name":"cyclic ADP-ribose","id":"cyclic-adp-ribose","score":0.5897,"url":"https://openalex.org/keywords/cyclic-adp-ribose"},{"display_name":"NAADP","id":"naadp","score":0.8083,"url":"https://openalex.org/keywords/naadp"},{"display_name":"TRPML1","id":"trpml1","score":0.6386,"url":"https://openalex.org/keywords/trpml1"},{"display_name":"ADP-ribosyl cyclase","id":"adp-ribosyl-cyclase","score":0.5305,"url":"https://openalex.org/keywords/adp-ribosyl-cyclase"},{"display_name":"two-pore channels","id":"two-pore-channels","score":0.4211,"url":"https://openalex.org/keywords/two-pore-channels"},{"display_name":"TPC2","id":"tpc2","score":0.6603,"url":"https://openalex.org/keywords/tpc2"},{"display_name":"TPC1","id":"tpc1","score":0.5474,"url":"https://openalex.org/keywords/tpc1"},{"display_name":"mucolipidosis type IV","id":"mucolipidosis-type-iv","score":0.4463,"url":"https://openalex.org/keywords/mucolipidosis-type-iv"},{"display_name":"lysosomal calcium release","id":"lysosomal-calcium-release","score":0.5728,"url":"https://openalex.org/keywords/lysosomal-calcium-release"},{"display_name":"MCOLN1","id":"mucolipin-1","score":0.3369,"url":"https://openalex.org/keywords/mucolipin-1"},{"display_name":"lysosomal ion channels","id":"lysosomal-ion-channels","score":0.7294,"url":"https://openalex.org/keywords/lysosomal-ion-channels"},{"display_name":"NAADP receptor","id":"naadp-receptor","score":0.9079,"url":"https://openalex.org/keywords/naadp-receptor"},{"display_name":"TRPML3","id":"trpml3","score":0.6806,"url":"https://openalex.org/keywords/trpml3"},{"display_name":"TRPML2","id":"trpml2","score":0.7914,"url":"https://openalex.org/keywords/trpml2"},{"display_name":"lysosomal calcium","id":"lysosomal-calcium","score":0.3359,"url":"https://openalex.org/keywords/lysosomal-calcium"},{"display_name":"PI(3,5)P2","id":"pi-3-5-p2","score":0.2543,"url":"https://openalex.org/keywords/pi-3-5-p2"},{"display_name":"NAD+ metabolites","id":"nad-metabolites","score":0.2798,"url":"https://openalex.org/keywords/nad-metabolites"},{"display_name":"TRPML","id":"trpml","score":0.2485,"url":"https://openalex.org/keywords/trpml"}],"legacy_keywords":["Lysosomal Calcium Signaling","Two-pore Channels","NAADP","TRPML1","Endolysosomal Trafficking","Cyclic ADP-Ribose","Mucolipidosis Type IV","Intracellular Calcium Release","Nicotinic Acid Adenine Dinucleotide Phosphate","Lysosomal Storage Diseases"],"openalex_id":"https://openalex.org/T13415","source_created_date":"2024-01-23T15:27:18","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1314","url":"/topics/T13415","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13415","works_count":5242,"label":"Calcium signaling and nucleotide metabolism","provider":"openalex","revision":"048e32e6e989b74e","taxonomy_revision":"f050b5d4780b1289","title":"Calcium signaling and nucleotide metabolism","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38293808298863307","address_version":"morton4x16-v1","coordinates":[1,13,1314,13415],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}