TGF-β signaling in diseases
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Scope of this subject
This cluster of papers explores the diverse aspects of the Transforming Growth Factor Beta (TGF-ß) signaling pathway, including its role in Smad-dependent and Smad-independent pathways, tumor suppression, cancer progression, bone morphogenetic protein (BMP) signaling, immune response modulation, cell differentiation, metastasis, regulation of epithelial-mesenchymal transition (EMT), and angiogenesis. It also discusses the development and use of TGF-ß inhibitors for potential therapeutic interventions.
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Research vocabulary
TGF-beta signaling; Smad3; SMAD4; TGFBR2; TGF-beta superfamily; Smad2; Smad7; Smad signaling; TGF-beta receptor; TGF-beta type I receptor; Smad proteins; Smad2 phosphorylation; Smad2/3; Smad1; Smad2/3 phosphorylation; ALK5; TGF-beta isoforms; Smad3 phosphorylation; Smad6; Smad phosphorylation; SB431542; TGF-beta activation; TGF-beta resistance; BMP receptors; TGF-β inhibitors
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Local answer status
No owner-reviewed answer has been published for this exact subject page. This is a gap in this collection; it does not establish that the answer is unavailable elsewhere.
Numeric address and provenance
Morton address: 36182748121049611 · morton4x16-v1
Coordinates: (1, 13, 1312, 11501). The address interleaves categorical identifier bits. Nearby addresses are not guaranteed to describe semantically similar subjects.
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