{"cited_by_count":1382173,"description":"This cluster of papers explores the diverse aspects of the Transforming Growth Factor Beta (TGF-\u00df) signaling pathway, including its role in Smad-dependent and Smad-independent pathways, tumor suppression, cancer progression, bone morphogenetic protein (BMP) signaling, immune response modulation, cell differentiation, metastasis, regulation of epithelial-mesenchymal transition (EMT), and angiogenesis. It also discusses the development and use of TGF-\u00df inhibitors for potential therapeutic interventions.","display_name":"TGF-\u03b2 signaling in diseases","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11501","wikipedia":"https://en.wikipedia.org/wiki/TGF_beta_signaling_pathway"},"field_id":"13","id":"T11501","keywords":[{"display_name":"TGF-beta signaling","id":"tgf-beta-signaling","score":0.2316,"url":"https://openalex.org/keywords/tgf-beta-signaling"},{"display_name":"Smad3","id":"smad3","score":0.2977,"url":"https://openalex.org/keywords/smad3"},{"display_name":"SMAD4","id":"smad4","score":0.2728,"url":"https://openalex.org/keywords/smad4"},{"display_name":"TGFBR2","id":"tgf-beta-receptor-ii","score":0.2879,"url":"https://openalex.org/keywords/tgf-beta-receptor-ii"},{"display_name":"TGF-beta superfamily","id":"tgf-beta-superfamily","score":0.2805,"url":"https://openalex.org/keywords/tgf-beta-superfamily"},{"display_name":"Smad2","id":"smad2","score":0.3486,"url":"https://openalex.org/keywords/smad2"},{"display_name":"Smad7","id":"smad7","score":0.2886,"url":"https://openalex.org/keywords/smad7"},{"display_name":"Smad signaling","id":"smad-signaling","score":0.3108,"url":"https://openalex.org/keywords/smad-signaling"},{"display_name":"TGF-beta receptor","id":"tgf-beta-receptor","score":0.4137,"url":"https://openalex.org/keywords/tgf-beta-receptor"},{"display_name":"TGF-beta type I receptor","id":"tgf-beta-type-i-receptor","score":0.4188,"url":"https://openalex.org/keywords/tgf-beta-type-i-receptor"},{"display_name":"Smad proteins","id":"smad-proteins","score":0.647,"url":"https://openalex.org/keywords/smad-proteins"},{"display_name":"Smad2 phosphorylation","id":"smad2-phosphorylation","score":0.3398,"url":"https://openalex.org/keywords/smad2-phosphorylation"},{"display_name":"Smad2/3","id":"smad2-3","score":0.2542,"url":"https://openalex.org/keywords/smad2-3"},{"display_name":"Smad1","id":"smad1","score":0.281,"url":"https://openalex.org/keywords/smad1"},{"display_name":"Smad2/3 phosphorylation","id":"smad2-3-phosphorylation","score":0.2617,"url":"https://openalex.org/keywords/smad2-3-phosphorylation"},{"display_name":"ALK5","id":"alk5","score":0.3779,"url":"https://openalex.org/keywords/alk5"},{"display_name":"TGF-beta isoforms","id":"tgf-beta-isoforms","score":0.4193,"url":"https://openalex.org/keywords/tgf-beta-isoforms"},{"display_name":"Smad3 phosphorylation","id":"smad3-phosphorylation","score":0.3115,"url":"https://openalex.org/keywords/smad3-phosphorylation"},{"display_name":"Smad6","id":"smad6","score":0.3156,"url":"https://openalex.org/keywords/smad6"},{"display_name":"Smad phosphorylation","id":"smad-phosphorylation","score":0.4724,"url":"https://openalex.org/keywords/smad-phosphorylation"},{"display_name":"SB431542","id":"sb-431542","score":0.2102,"url":"https://openalex.org/keywords/sb-431542"},{"display_name":"TGF-beta activation","id":"tgf-beta-activation","score":0.3215,"url":"https://openalex.org/keywords/tgf-beta-activation"},{"display_name":"TGF-beta resistance","id":"tgf-beta-resistance","score":0.6347,"url":"https://openalex.org/keywords/tgf-beta-resistance"},{"display_name":"BMP receptors","id":"bmp-receptors","score":0.3194,"url":"https://openalex.org/keywords/bmp-receptors"},{"display_name":"TGF-\u03b2 inhibitors","id":"tgf-beta-inhibitors","score":0.3484,"url":"https://openalex.org/keywords/tgf-beta-inhibitors"}],"legacy_keywords":["Smad-dependent pathways","Tumor Suppression","Cancer Progression","BMP signaling","Immune Response","Cell Differentiation","Metastasis","Regulation of EMT","Angiogenesis","TGF-\u00df Inhibitors"],"openalex_id":"https://openalex.org/T11501","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T11501","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11501","works_count":37183,"label":"TGF-\u03b2 signaling in diseases","provider":"openalex","revision":"f13eef76156da4b6","taxonomy_revision":"f050b5d4780b1289","title":"TGF-\u03b2 signaling in diseases","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36182748121049611","address_version":"morton4x16-v1","coordinates":[1,13,1312,11501],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}