Endoplasmic Reticulum Stress and Disease
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Scope of this subject
This cluster of papers focuses on the molecular mechanisms, regulation, and consequences of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). It explores the role of ER stress in various diseases such as diabetes, cancer, neurodegenerative diseases, and liver disease, highlighting its impact on cell fate decisions, protein folding, oxidative stress, and apoptosis. The cluster also delves into the involvement of UPR pathways, chaperones, and the interplay between ER stress and inflammation.
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Research vocabulary
endoplasmic reticulum stress; unfolded protein response; GRP78; CHOP; ER-associated degradation; PERK; ATF6; IRE1α; tunicamycin; ATF4; XBP1; IRE1; eIF2α phosphorylation; BiP; XBP1 splicing; caspase-12; integrated stress response; 4-phenylbutyric acid; calnexin; eIF2α; GRP94; ER stress response; endoplasmic reticulum stress response; ER chaperones; ER homeostasis
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No owner-reviewed answer has been published for this exact subject page. This is a gap in this collection; it does not establish that the answer is unavailable elsewhere.
Numeric address and provenance
Morton address: 36174535997057735 · morton4x16-v1
Coordinates: (1, 13, 1307, 11150). The address interleaves categorical identifier bits. Nearby addresses are not guaranteed to describe semantically similar subjects.
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