{"cited_by_count":1120862,"description":"This cluster of papers focuses on the molecular mechanisms, regulation, and consequences of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). It explores the role of ER stress in various diseases such as diabetes, cancer, neurodegenerative diseases, and liver disease, highlighting its impact on cell fate decisions, protein folding, oxidative stress, and apoptosis. The cluster also delves into the involvement of UPR pathways, chaperones, and the interplay between ER stress and inflammation.","display_name":"Endoplasmic Reticulum Stress and Disease","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11150","wikipedia":"https://en.wikipedia.org/wiki/Endoplasmic_reticulum_stress"},"field_id":"13","id":"T11150","keywords":[{"display_name":"endoplasmic reticulum stress","id":"endoplasmic-reticulum-stress","score":0.3055,"url":"https://openalex.org/keywords/endoplasmic-reticulum-stress"},{"display_name":"unfolded protein response","id":"unfolded-protein-response","score":0.4645,"url":"https://openalex.org/keywords/unfolded-protein-response"},{"display_name":"GRP78","id":"grp78","score":0.3357,"url":"https://openalex.org/keywords/grp78"},{"display_name":"CHOP","id":"chop","score":0.3638,"url":"https://openalex.org/keywords/chop"},{"display_name":"ER-associated degradation","id":"er-associated-degradation","score":0.4264,"url":"https://openalex.org/keywords/er-associated-degradation"},{"display_name":"PERK","id":"perk","score":0.5037,"url":"https://openalex.org/keywords/perk"},{"display_name":"ATF6","id":"atf6","score":0.5771,"url":"https://openalex.org/keywords/atf6"},{"display_name":"IRE1\u03b1","id":"ire1alpha","score":0.5377,"url":"https://openalex.org/keywords/ire1alpha"},{"display_name":"tunicamycin","id":"tunicamycin","score":0.2737,"url":"https://openalex.org/keywords/tunicamycin"},{"display_name":"ATF4","id":"atf4","score":0.2995,"url":"https://openalex.org/keywords/atf4"},{"display_name":"XBP1","id":"xbp1","score":0.3935,"url":"https://openalex.org/keywords/xbp1"},{"display_name":"IRE1","id":"ire1","score":0.6498,"url":"https://openalex.org/keywords/ire1"},{"display_name":"eIF2\u03b1 phosphorylation","id":"eif2alpha-phosphorylation","score":0.2959,"url":"https://openalex.org/keywords/eif2alpha-phosphorylation"},{"display_name":"BiP","id":"bip","score":0.4013,"url":"https://openalex.org/keywords/bip"},{"display_name":"XBP1 splicing","id":"xbp1-splicing","score":0.6589,"url":"https://openalex.org/keywords/xbp1-splicing"},{"display_name":"caspase-12","id":"caspase-12","score":0.2981,"url":"https://openalex.org/keywords/caspase-12"},{"display_name":"integrated stress response","id":"integrated-stress-response","score":0.2164,"url":"https://openalex.org/keywords/integrated-stress-response"},{"display_name":"4-phenylbutyric acid","id":"4-phenylbutyrate","score":0.2121,"url":"https://openalex.org/keywords/4-phenylbutyrate"},{"display_name":"calnexin","id":"calnexin","score":0.3178,"url":"https://openalex.org/keywords/calnexin"},{"display_name":"eIF2\u03b1","id":"eif2alpha","score":0.2886,"url":"https://openalex.org/keywords/eif2alpha"},{"display_name":"GRP94","id":"grp94","score":0.3428,"url":"https://openalex.org/keywords/grp94"},{"display_name":"ER stress response","id":"er-stress-response","score":0.497,"url":"https://openalex.org/keywords/er-stress-response"},{"display_name":"endoplasmic reticulum stress response","id":"endoplasmic-reticulum-stress-response","score":0.4381,"url":"https://openalex.org/keywords/endoplasmic-reticulum-stress-response"},{"display_name":"ER chaperones","id":"er-chaperones","score":0.6133,"url":"https://openalex.org/keywords/er-chaperones"},{"display_name":"ER homeostasis","id":"er-homeostasis","score":0.688,"url":"https://openalex.org/keywords/er-homeostasis"}],"legacy_keywords":["Endoplasmic Reticulum","Stress","Unfolded Protein Response","ER Stress","Cell Death","Protein Folding","UPR Pathways","Oxidative Stress","Apoptosis","Chaperones"],"openalex_id":"https://openalex.org/T11150","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T11150","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11150","works_count":31311,"label":"Endoplasmic Reticulum Stress and Disease","provider":"openalex","revision":"c431504b14640910","taxonomy_revision":"f050b5d4780b1289","title":"Endoplasmic Reticulum Stress and Disease","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36174535997057735","address_version":"morton4x16-v1","coordinates":[1,13,1307,11150],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}