Drug Transport and Resistance Mechanisms
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Scope of this subject
This cluster of papers explores the mechanisms of multidrug resistance in cancer, focusing on the role of ATP-dependent transporters, P-glycoprotein, bile acids, ABC transporters, and drug efflux pumps. It also delves into the involvement of nuclear receptors, metabolic regulation, and the impact on intestinal barrier function.
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Research vocabulary
P-glycoprotein; ABC transporters; drug efflux; ABCG2; drug transporters; MDR1; efflux pumps; MRP2; MRP1; multidrug resistance reversal; biliary excretion; doxorubicin resistance; drug transport; drug resistance reversal; multidrug resistance protein; MDR1 gene; multidrug resistance-associated protein; farnesoid X receptor; organic anion transporters; drug accumulation; bile acid transport; organic anion transporting polypeptides; P-glycoprotein inhibitors; drug efflux pumps; organic cation transporters
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Numeric address and provenance
Morton address: 36240213701485026 · morton4x16-v1
Coordinates: (4, 27, 2730, 10570). The address interleaves categorical identifier bits. Nearby addresses are not guaranteed to describe semantically similar subjects.
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