{"cited_by_count":2313074,"description":"This cluster of papers explores the mechanisms of multidrug resistance in cancer, focusing on the role of ATP-dependent transporters, P-glycoprotein, bile acids, ABC transporters, and drug efflux pumps. It also delves into the involvement of nuclear receptors, metabolic regulation, and the impact on intestinal barrier function.","display_name":"Drug Transport and Resistance Mechanisms","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10570","wikipedia":"https://en.wikipedia.org/wiki/Multidrug_resistance"},"field_id":"27","id":"T10570","keywords":[{"display_name":"P-glycoprotein","id":"p-glycoprotein","score":0.547,"url":"https://openalex.org/keywords/p-glycoprotein"},{"display_name":"ABC transporters","id":"abc-transporters","score":0.3902,"url":"https://openalex.org/keywords/abc-transporters"},{"display_name":"drug efflux","id":"drug-efflux","score":0.6746,"url":"https://openalex.org/keywords/drug-efflux"},{"display_name":"ABCG2","id":"abcg2","score":0.4853,"url":"https://openalex.org/keywords/abcg2"},{"display_name":"drug transporters","id":"drug-transporters","score":0.479,"url":"https://openalex.org/keywords/drug-transporters"},{"display_name":"MDR1","id":"mdr1","score":0.4921,"url":"https://openalex.org/keywords/mdr1"},{"display_name":"efflux pumps","id":"efflux-pumps","score":0.2633,"url":"https://openalex.org/keywords/efflux-pumps"},{"display_name":"MRP2","id":"mrp2","score":0.5934,"url":"https://openalex.org/keywords/mrp2"},{"display_name":"MRP1","id":"mrp1","score":0.5902,"url":"https://openalex.org/keywords/mrp1"},{"display_name":"multidrug resistance reversal","id":"multidrug-resistance-reversal","score":0.6787,"url":"https://openalex.org/keywords/multidrug-resistance-reversal"},{"display_name":"biliary excretion","id":"biliary-excretion","score":0.2252,"url":"https://openalex.org/keywords/biliary-excretion"},{"display_name":"doxorubicin resistance","id":"doxorubicin-resistance","score":0.3377,"url":"https://openalex.org/keywords/doxorubicin-resistance"},{"display_name":"drug transport","id":"drug-transport","score":0.3999,"url":"https://openalex.org/keywords/drug-transport"},{"display_name":"drug resistance reversal","id":"reversal-of-drug-resistance","score":0.419,"url":"https://openalex.org/keywords/reversal-of-drug-resistance"},{"display_name":"multidrug resistance protein","id":"multidrug-resistance-protein","score":0.6499,"url":"https://openalex.org/keywords/multidrug-resistance-protein"},{"display_name":"MDR1 gene","id":"abcb1-gene","score":0.603,"url":"https://openalex.org/keywords/abcb1-gene"},{"display_name":"multidrug resistance-associated protein","id":"multidrug-resistance-associated-protein","score":0.7394,"url":"https://openalex.org/keywords/multidrug-resistance-associated-protein"},{"display_name":"farnesoid X receptor","id":"farnesoid-x-receptor","score":0.2327,"url":"https://openalex.org/keywords/farnesoid-x-receptor"},{"display_name":"organic anion transporters","id":"organic-anion-transporters","score":0.6633,"url":"https://openalex.org/keywords/organic-anion-transporters"},{"display_name":"drug accumulation","id":"drug-accumulation","score":0.22,"url":"https://openalex.org/keywords/drug-accumulation"},{"display_name":"bile acid transport","id":"bile-acid-transport","score":0.6625,"url":"https://openalex.org/keywords/bile-acid-transport"},{"display_name":"organic anion transporting polypeptides","id":"organic-anion-transporting-polypeptides","score":0.6918,"url":"https://openalex.org/keywords/organic-anion-transporting-polypeptides"},{"display_name":"P-glycoprotein inhibitors","id":"p-glycoprotein-inhibitors","score":0.6524,"url":"https://openalex.org/keywords/p-glycoprotein-inhibitors"},{"display_name":"drug efflux pumps","id":"drug-efflux-pumps","score":0.5571,"url":"https://openalex.org/keywords/drug-efflux-pumps"},{"display_name":"organic cation transporters","id":"organic-cation-transporters","score":0.6194,"url":"https://openalex.org/keywords/organic-cation-transporters"}],"legacy_keywords":["Multidrug Resistance","ATP-dependent Transporters","P-glycoprotein","Bile Acids","ABC Transporters","Drug Efflux Pumps","Nuclear Receptors","Cancer Chemotherapy","Metabolic Regulation","Intestinal Barrier"],"openalex_id":"https://openalex.org/T10570","source_created_date":"2024-01-23T15:27:07","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T10570","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10570","works_count":89761,"label":"Drug Transport and Resistance Mechanisms","provider":"openalex","revision":"4ac103ee6d87f5e7","taxonomy_revision":"f050b5d4780b1289","title":"Drug Transport and Resistance Mechanisms","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240213701485026","address_version":"morton4x16-v1","coordinates":[4,27,2730,10570],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}