Metabolism, Diabetes, and Cancer
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Scope of this subject
This cluster of papers explores the role of AMP-activated protein kinase (AMPK) in regulating cellular metabolism, including its involvement in glucose and lipid metabolism, insulin signaling, mitochondrial homeostasis, and the potential impact on cancer risk. The cluster also delves into the mechanisms of action of metformin, a drug known to activate AMPK and its effects on cellular energy balance and gene expression regulation.
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Research vocabulary
glucose transport; GLUT4; GLUT4 translocation; glycogen synthase; AMPK activation; AICAR; insulin binding; insulin-stimulated glucose uptake; insulin-stimulated glucose transport; skeletal muscle glucose uptake; 2-deoxyglucose uptake; insulin receptor substrate; energy sensing; AMPK activators; AMPK phosphorylation; AS160; insulin receptor tyrosine kinase; muscle glucose uptake; AMPKα2; AMP/ATP ratio; L6 myotubes; hexose transport; epitrochlearis muscle; diabetes and cancer association; AMPKα1
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Numeric address and provenance
Morton address: 36182745965175435 · morton4x16-v1
Coordinates: (1, 13, 1312, 11339). The address interleaves categorical identifier bits. Nearby addresses are not guaranteed to describe semantically similar subjects.
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