Genomics, phytochemicals, and oxidative stress
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Scope of this subject
This cluster of papers focuses on the role of Nrf2 signaling in oxidative stress response, including its activation by oxidative stress, regulation of antioxidant gene expression, and its impact on cancer, inflammation, and chemoprevention. The Keap1-Nrf2-ARE pathway and the chemical diversity of glucosinolates are also central to this topic.
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Research vocabulary
Nrf2; Keap1; sulforaphane; antioxidant response element; NQO1; cruciferous vegetables; Nrf2/Keap1 pathway; Nrf2 activation; phase II enzymes; Nrf2 nuclear translocation; myrosinase; Nrf2/ARE pathway; Nrf2 activators; glucoraphanin; phenethyl isothiocyanate; Nrf2 knockout mice; benzyl isothiocyanate; GCLC; Nrf2 inhibitors; electrophilic stress; broccoli sprouts; Nrf2 target genes; Keap1-Nrf2 interaction; KEAP1 mutation; glucobrassicin
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Numeric address and provenance
Morton address: 36182745965144579 · morton4x16-v1
Coordinates: (1, 13, 1312, 11332). The address interleaves categorical identifier bits. Nearby addresses are not guaranteed to describe semantically similar subjects.
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