Protein purification and stability
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Scope of this subject
This cluster of papers focuses on the analysis, mechanisms, and control of protein aggregation in biopharmaceuticals, particularly recombinant proteins and therapeutic antibodies. It also delves into the stability, chromatographic purification, immunogenicity, and refolding of these proteins, as well as the use of sedimentation velocity for size-distribution analysis.
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Research vocabulary
inclusion bodies; affinity chromatography; protein refolding; recombinant protein purification; downstream processing; antibody purification; hydrophobic interaction chromatography; immobilized metal affinity chromatography; monoclonal antibody purification; cation exchange chromatography; soluble protein expression; protein renaturation; protein formulation; endotoxin removal; sedimentation equilibrium; analytical ultracentrifugation; dynamic binding capacity; host cell proteins; biopharmaceutical purification; IgG purification; plasmid DNA purification; protein A affinity chromatography; expanded bed adsorption; membrane chromatography; host cell protein removal
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Numeric address and provenance
Morton address: 36174533996587523 · morton4x16-v1
Coordinates: (1, 13, 1312, 11124). The address interleaves categorical identifier bits. Nearby addresses are not guaranteed to describe semantically similar subjects.
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