# Advanced Breast Cancer Therapies { "id": "T12829", "title": "Advanced Breast Cancer Therapies", "url": "/topics/T12829", "kind": "topic-directory", "aeo_cohort": "topic-directory", "provider": "openalex", "revision": "e5c9e52f2a554e9f", "catalogue_revision": "f050b5d4780b1289", "numeric_address": "38351791289445674", "address_version": "morton4x16-v1", "coordinates": [ 4, 27, 2740, 12829 ], "answer_status": "Directory metadata; local answer requires separate source review", "truth_status": "Subject descriptor, not a factual answer or a demonstrated knowledge gap" } This cluster of papers focuses on the use of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, such as palbociclib, letrozole, ribociclib, and abemaciclib, in the treatment of hormone receptor-positive metastatic breast cancer. The papers cover various aspects including clinical trials, mechanisms of action, therapeutic resistance, combination strategies, and potential biomarkers. Directory metadata is not a factual answer or evidence of a global knowledge gap. Source: https://openalex.org/T12829 No owner-reviewed local answer yet.