# Pain Management and Placebo Effect { "id": "T12035", "title": "Pain Management and Placebo Effect", "url": "/topics/T12035", "kind": "topic-directory", "aeo_cohort": "topic-directory", "provider": "openalex", "revision": "bf9008a724194a8c", "catalogue_revision": "f050b5d4780b1289", "numeric_address": "36249559483426445", "address_version": "morton4x16-v1", "coordinates": [ 1, 28, 2805, 12035 ], "answer_status": "Directory metadata; local answer requires separate source review", "truth_status": "Subject descriptor, not a factual answer or a demonstrated knowledge gap" } This cluster of papers explores the neurobiological mechanisms underlying placebo and nocebo effects, focusing on the role of expectation, pain perception, opioid activity, dopamine release, and the use of functional magnetic resonance imaging in clinical trials. It also delves into the impact of hypnosis on pain relief and the modulation of patient outcomes through placebo responses. Directory metadata is not a factual answer or evidence of a global knowledge gap. Source: https://openalex.org/T12035 No owner-reviewed local answer yet.