# Cancer therapeutics and mechanisms

{
  "id": "T11845",
  "title": "Cancer therapeutics and mechanisms",
  "url": "/topics/T11845",
  "kind": "topic-directory",
  "aeo_cohort": "topic-directory",
  "provider": "openalex",
  "revision": "cb32d2b8efe78ba9",
  "catalogue_revision": "f050b5d4780b1289",
  "numeric_address": "36183295720958475",
  "address_version": "morton4x16-v1",
  "coordinates": [
    1,
    13,
    1312,
    11845
  ],
  "answer_status": "Directory metadata; local answer requires separate source review",
  "truth_status": "Subject descriptor, not a factual answer or a demonstrated knowledge gap"
}

This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.

Directory metadata is not a factual answer or evidence of a global knowledge gap.

Source: https://openalex.org/T11845

No owner-reviewed local answer yet.