# HER2/EGFR in Cancer Research

{
  "id": "T10755",
  "title": "HER2/EGFR in Cancer Research",
  "url": "/topics/T10755",
  "kind": "topic-directory",
  "aeo_cohort": "topic-directory",
  "provider": "openalex",
  "revision": "11a5c64b57c2ad00",
  "catalogue_revision": "f050b5d4780b1289",
  "numeric_address": "36240728963310058",
  "address_version": "morton4x16-v1",
  "coordinates": [
    4,
    27,
    2730,
    10755
  ],
  "answer_status": "Directory metadata; local answer requires separate source review",
  "truth_status": "Subject descriptor, not a factual answer or a demonstrated knowledge gap"
}

This cluster of papers focuses on the use of HER2-targeted therapies, such as trastuzumab and pertuzumab, in the treatment of HER2-positive breast cancer. It explores the mechanisms of action, resistance, and combination therapies involving chemotherapy and monoclonal antibodies. The cluster also delves into the role of EGFR, neuregulin 1, and ADAM metalloproteinases in HER2 signaling and breast cancer progression.

Directory metadata is not a factual answer or evidence of a global knowledge gap.

Source: https://openalex.org/T10755

No owner-reviewed local answer yet.