{"cited_by_count":229298,"description":"This cluster of papers explores the role of Urotensin II in cardiovascular physiology and disease, focusing on its vasoconstrictor activity, impact on hypertension, atherosclerosis, endothelial dysfunction, and renal function. It also discusses the development of receptor antagonists and its involvement in smooth muscle cell proliferation and the neuroendocrine system.","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T14486","wikipedia":"https://en.wikipedia.org/wiki/Urotensin_II"},"field_id":"27","id":"T14486","keywords":[{"display_name":"urotensin II","id":"urotensin-ii","score":0.4278,"url":"https://openalex.org/keywords/urotensin-ii"},{"display_name":"natriuretic peptide receptors","id":"natriuretic-peptide-receptors","score":0.3105,"url":"https://openalex.org/keywords/natriuretic-peptide-receptors"},{"display_name":"urotensin II receptor","id":"urotensin-ii-receptor","score":0.4813,"url":"https://openalex.org/keywords/urotensin-ii-receptor"},{"display_name":"ANP receptors","id":"anp-receptors","score":0.4511,"url":"https://openalex.org/keywords/anp-receptors"},{"display_name":"cardiac hormones","id":"cardiac-hormones","score":0.2749,"url":"https://openalex.org/keywords/cardiac-hormones"},{"display_name":"ANF receptors","id":"anf-receptors","score":0.5055,"url":"https://openalex.org/keywords/anf-receptors"},{"display_name":"NPR-C","id":"natriuretic-peptide-receptor-c","score":0.2228,"url":"https://openalex.org/keywords/natriuretic-peptide-receptor-c"},{"display_name":"natriuretic peptide receptor B","id":"natriuretic-peptide-receptor-b","score":0.21,"url":"https://openalex.org/keywords/natriuretic-peptide-receptor-b"},{"display_name":"ANP secretion","id":"anp-secretion","score":0.346,"url":"https://openalex.org/keywords/anp-secretion"},{"display_name":"atriopeptin","id":"atriopeptin","score":0.383,"url":"https://openalex.org/keywords/atriopeptin"},{"display_name":"atriopeptin III","id":"atriopeptin-iii","score":0.3907,"url":"https://openalex.org/keywords/atriopeptin-iii"},{"display_name":"atrial peptides","id":"atrial-peptides","score":0.4758,"url":"https://openalex.org/keywords/atrial-peptides"},{"display_name":"GPR14","id":"gpr14","score":0.5483,"url":"https://openalex.org/keywords/gpr14"},{"display_name":"ANP release","id":"anp-release","score":0.4437,"url":"https://openalex.org/keywords/anp-release"},{"display_name":"atrial distension","id":"atrial-distension","score":0.2856,"url":"https://openalex.org/keywords/atrial-distension"},{"display_name":"salusin-\u03b2","id":"salusin-beta","score":0.2855,"url":"https://openalex.org/keywords/salusin-beta"},{"display_name":"urotensin I","id":"urotensin-i","score":0.2093,"url":"https://openalex.org/keywords/urotensin-i"},{"display_name":"urantide","id":"urantide","score":0.4505,"url":"https://openalex.org/keywords/urantide"},{"display_name":"plasma ANP","id":"plasma-anp","score":0.2577,"url":"https://openalex.org/keywords/plasma-anp"},{"display_name":"atriopeptin II","id":"atriopeptin-ii","score":0.3919,"url":"https://openalex.org/keywords/atriopeptin-ii"},{"display_name":"urotensin II-related peptide","id":"urotensin-ii-related-peptide","score":0.4993,"url":"https://openalex.org/keywords/urotensin-ii-related-peptide"},{"display_name":"urotensin receptor","id":"urotensin-receptor","score":0.458,"url":"https://openalex.org/keywords/urotensin-receptor"},{"display_name":"natriuretic peptide signaling","id":"natriuretic-peptide-signaling","score":0.2221,"url":"https://openalex.org/keywords/natriuretic-peptide-signaling"},{"display_name":"natriuretic activity","id":"natriuretic-activity","score":0.2111,"url":"https://openalex.org/keywords/natriuretic-activity"},{"display_name":"vasostatin","id":"vasostatin","score":0.2207,"url":"https://openalex.org/keywords/vasostatin"}],"legacy_keywords":["Urotensin II","Cardiovascular Disease","Vasoconstriction","Hypertension","Atherosclerosis","Receptor Antagonist","Smooth Muscle Cell Proliferation","Endothelial Dysfunction","Renal Function","Neuroendocrine System"],"openalex_id":"https://openalex.org/T14486","source_created_date":"2024-01-23T15:27:22","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2746","url":"/topics/T14486","works_api_url":"https://api.openalex.org/works?filter=topics.id:T14486","works_count":12437,"label":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","provider":"openalex","revision":"eaf0b6c16d956a67","taxonomy_revision":"f050b5d4780b1289","title":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38491981169453538","address_version":"morton4x16-v1","coordinates":[4,27,2746,14486],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}