{"cited_by_count":186106,"description":"This cluster of papers explores the role of pentraxins, particularly PTX3, in innate immunity, inflammation, cardiovascular diseases, tissue remodeling, infection, autoimmunity, and cancer. The research covers various aspects of pentraxin function, including pattern recognition, interaction with complement system, biomarker potential, and therapeutic implications.","display_name":"Biomarkers in Disease Mechanisms","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T14245","wikipedia":"https://en.wikipedia.org/wiki/Pentraxin_3"},"field_id":"24","id":"T14245","keywords":[{"display_name":"pentraxin 3","id":"pentraxin-3","score":0.2796,"url":"https://openalex.org/keywords/pentraxin-3"},{"display_name":"pentraxins","id":"pentraxins","score":0.5153,"url":"https://openalex.org/keywords/pentraxins"},{"display_name":"long pentraxin","id":"long-pentraxin","score":0.823,"url":"https://openalex.org/keywords/long-pentraxin"},{"display_name":"monomeric C-reactive protein","id":"monomeric-c-reactive-protein","score":0.3771,"url":"https://openalex.org/keywords/monomeric-c-reactive-protein"},{"display_name":"pentameric CRP","id":"pentameric-crp","score":0.744,"url":"https://openalex.org/keywords/pentameric-crp"},{"display_name":"monomeric CRP","id":"monomeric-crp","score":0.6407,"url":"https://openalex.org/keywords/monomeric-crp"},{"display_name":"pneumococcal C-polysaccharide","id":"pneumococcal-c-polysaccharide","score":0.3947,"url":"https://openalex.org/keywords/pneumococcal-c-polysaccharide"}],"legacy_keywords":["Pentraxins","Innate Immunity","Inflammation","Pattern Recognition","PTX3","Cardiovascular Disease","Tissue Remodeling","Infection","Autoimmunity","Cancer"],"openalex_id":"https://openalex.org/T14245","source_created_date":"2024-01-23T15:27:21","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T14245","works_api_url":"https://api.openalex.org/works?filter=topics.id:T14245","works_count":7670,"label":"Biomarkers in Disease Mechanisms","provider":"openalex","revision":"01d2abe4e7047bd9","taxonomy_revision":"f050b5d4780b1289","title":"Biomarkers in Disease Mechanisms","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38360365192587341","address_version":"morton4x16-v1","coordinates":[1,24,2403,14245],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}