{"cited_by_count":115216,"description":"This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds.","display_name":"Synthesis and Biological Activity","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13971","wikipedia":"https://en.wikipedia.org/wiki/Tetrahydroisoquinoline_antitumor_antibiotics"},"field_id":"13","id":"T13971","keywords":[{"display_name":"tetrahydroisoquinolines","id":"tetrahydroisoquinolines","score":0.3467,"url":"https://openalex.org/keywords/tetrahydroisoquinolines"},{"display_name":"isoquinoline alkaloids","id":"isoquinoline-alkaloids","score":0.248,"url":"https://openalex.org/keywords/isoquinoline-alkaloids"},{"display_name":"isoquinoline derivatives","id":"isoquinoline-derivatives","score":0.3184,"url":"https://openalex.org/keywords/isoquinoline-derivatives"},{"display_name":"isoquinoline synthesis","id":"isoquinoline-synthesis","score":0.4539,"url":"https://openalex.org/keywords/isoquinoline-synthesis"},{"display_name":"tetrahydroisoquinoline alkaloids","id":"tetrahydroisoquinoline-alkaloids","score":0.4028,"url":"https://openalex.org/keywords/tetrahydroisoquinoline-alkaloids"},{"display_name":"tetrahydroisoquinoline derivatives","id":"tetrahydroisoquinoline-derivatives","score":0.3824,"url":"https://openalex.org/keywords/tetrahydroisoquinoline-derivatives"},{"display_name":"3,4-dihydroisoquinolines","id":"3-4-dihydroisoquinolines","score":0.3978,"url":"https://openalex.org/keywords/3-4-dihydroisoquinolines"},{"display_name":"tetrahydroisoquinoline synthesis","id":"tetrahydroisoquinoline-synthesis","score":0.6991,"url":"https://openalex.org/keywords/tetrahydroisoquinoline-synthesis"},{"display_name":"Bischler-Napieralski reaction","id":"bischler-napieralski-reaction","score":0.3603,"url":"https://openalex.org/keywords/bischler-napieralski-reaction"},{"display_name":"dihydroisoquinolines","id":"dihydroisoquinolines","score":0.2984,"url":"https://openalex.org/keywords/dihydroisoquinolines"},{"display_name":"Bischler-Napieralski cyclization","id":"bischler-napieralski-cyclization","score":0.3464,"url":"https://openalex.org/keywords/bischler-napieralski-cyclization"},{"display_name":"naphthylisoquinoline alkaloids","id":"naphthylisoquinoline-alkaloids","score":0.2834,"url":"https://openalex.org/keywords/naphthylisoquinoline-alkaloids"},{"display_name":"1,2-dihydroisoquinolines","id":"1-2-dihydroisoquinolines","score":0.2977,"url":"https://openalex.org/keywords/1-2-dihydroisoquinolines"},{"display_name":"isoquinolinium salts","id":"isoquinolinium-salts","score":0.2038,"url":"https://openalex.org/keywords/isoquinolinium-salts"},{"display_name":"homoveratrylamine","id":"homoveratrylamine","score":0.2857,"url":"https://openalex.org/keywords/homoveratrylamine"},{"display_name":"protoberberines","id":"protoberberines","score":0.227,"url":"https://openalex.org/keywords/protoberberines"},{"display_name":"decahydroisoquinoline","id":"decahydroisoquinoline","score":0.2912,"url":"https://openalex.org/keywords/decahydroisoquinoline"},{"display_name":"tetrahydroprotoberberines","id":"tetrahydroprotoberberines","score":0.2006,"url":"https://openalex.org/keywords/tetrahydroprotoberberines"},{"display_name":"salsolidine","id":"salsolidine","score":0.2782,"url":"https://openalex.org/keywords/salsolidine"},{"display_name":"ecteinascidins","id":"ecteinascidins","score":0.2323,"url":"https://openalex.org/keywords/ecteinascidins"},{"display_name":"phthalideisoquinoline alkaloids","id":"phthalideisoquinoline-alkaloids","score":0.3499,"url":"https://openalex.org/keywords/phthalideisoquinoline-alkaloids"},{"display_name":"xylopinine","id":"xylopinine","score":0.2698,"url":"https://openalex.org/keywords/xylopinine"},{"display_name":"benzyltetrahydroisoquinoline alkaloids","id":"benzyltetrahydroisoquinoline-alkaloids","score":0.2307,"url":"https://openalex.org/keywords/benzyltetrahydroisoquinoline-alkaloids"},{"display_name":"aromatic amine synthesis","id":"aromatic-amine-synthesis","score":0.4724,"url":"https://openalex.org/keywords/aromatic-amine-synthesis"}],"legacy_keywords":["Tetrahydroisoquinoline","Ecteinascidin","Total Synthesis","Anticancer Drug","Marine-derived Compound","Cycloaddition Reactions","Asymmetric Synthesis","Isocoumarins","Pharmacology","DNA Binding"],"openalex_id":"https://openalex.org/T13971","source_created_date":"2024-01-23T15:27:20","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1306","url":"/topics/T13971","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13971","works_count":12796,"label":"Synthesis and Biological Activity","provider":"openalex","revision":"3c0e01540030aa8e","taxonomy_revision":"f050b5d4780b1289","title":"Synthesis and Biological Activity","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38294360056160971","address_version":"morton4x16-v1","coordinates":[1,13,1306,13971],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}