{"cited_by_count":34765,"description":"This cluster of papers focuses on the development and evaluation of protein phosphatase inhibitors, such as Cantharidin and Norcantharidin, as potential anticancer agents. The research involves studying their mechanisms of action, including induction of apoptosis, cell cycle arrest, and inhibition of cancer cell growth. Additionally, the cluster explores the molecular identification of pederin biosynthesis and the pharmacological evaluation of these inhibitors.","display_name":"Beetle Biology and Toxicology Studies","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13943","wikipedia":"https://en.wikipedia.org/wiki/Protein_phosphatase_inhibitor"},"field_id":"13","id":"T13943","keywords":[{"display_name":"cantharidin","id":"cantharidin","score":0.506,"url":"https://openalex.org/keywords/cantharidin"},{"display_name":"norcantharidin","id":"norcantharidin","score":0.5389,"url":"https://openalex.org/keywords/norcantharidin"},{"display_name":"cantharides","id":"cantharides","score":0.5131,"url":"https://openalex.org/keywords/cantharides"},{"display_name":"Paederus dermatitis","id":"paederus-dermatitis","score":0.6127,"url":"https://openalex.org/keywords/paederus-dermatitis"},{"display_name":"Paederus","id":"paederus","score":0.3149,"url":"https://openalex.org/keywords/paederus"},{"display_name":"Cantharidus","id":"cantharidus","score":0.552,"url":"https://openalex.org/keywords/cantharidus"},{"display_name":"bombardier beetles","id":"bombardier-beetles","score":0.3308,"url":"https://openalex.org/keywords/bombardier-beetles"},{"display_name":"pederin","id":"pederin","score":0.3556,"url":"https://openalex.org/keywords/pederin"},{"display_name":"insect bite dermatitis","id":"insect-bite-dermatitis","score":0.2445,"url":"https://openalex.org/keywords/insect-bite-dermatitis"},{"display_name":"Mylabris","id":"mylabris","score":0.2149,"url":"https://openalex.org/keywords/mylabris"},{"display_name":"insect chemical defense","id":"insect-chemical-defense","score":0.2361,"url":"https://openalex.org/keywords/insect-chemical-defense"},{"display_name":"insect secondary metabolites","id":"insect-secondary-metabolites","score":0.2696,"url":"https://openalex.org/keywords/insect-secondary-metabolites"},{"display_name":"Spanish fly","id":"spanish-fly","score":0.3844,"url":"https://openalex.org/keywords/spanish-fly"},{"display_name":"Mylabris phalerata","id":"mylabris-phalerata","score":0.3422,"url":"https://openalex.org/keywords/mylabris-phalerata"}],"legacy_keywords":["Protein Phosphatase Inhibitors","Cantharidin","Norcantharidin","Anticancer Activity","Apoptosis","Cell Cycle Arrest","Sponge-Derived Cytotoxin","Pederin Biosynthesis","Molecular Identification","Pharmacological Evaluation"],"openalex_id":"https://openalex.org/T13943","source_created_date":"2024-01-23T15:27:20","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1306","url":"/topics/T13943","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13943","works_count":3415,"label":"Beetle Biology and Toxicology Studies","provider":"openalex","revision":"2e9295dc552b6666","taxonomy_revision":"f050b5d4780b1289","title":"Beetle Biology and Toxicology Studies","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38294358051285707","address_version":"morton4x16-v1","coordinates":[1,13,1306,13943],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}