{"cited_by_count":169380,"description":"This cluster of papers explores the role of calpain, a calcium-dependent protease, in regulating various cellular processes such as cell migration, neurodegeneration, apoptosis, and its involvement in diseases including diabetes, cancer, and cardiovascular remodeling. The papers also discuss the structure, activation, and inhibition of calpain as a potential therapeutic target.","display_name":"Calpain Protease Function and Regulation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13637","wikipedia":"https://en.wikipedia.org/wiki/Calpain"},"field_id":"13","id":"T13637","keywords":[{"display_name":"calpain","id":"calpain","score":0.3412,"url":"https://openalex.org/keywords/calpain"},{"display_name":"calpain-1","id":"calpain-1","score":0.4085,"url":"https://openalex.org/keywords/calpain-1"},{"display_name":"m-calpain","id":"calpain-2","score":0.5422,"url":"https://openalex.org/keywords/calpain-2"},{"display_name":"calpastatin","id":"calpastatin","score":0.4302,"url":"https://openalex.org/keywords/calpastatin"},{"display_name":"calpain inhibitors","id":"calpain-inhibitors","score":0.5824,"url":"https://openalex.org/keywords/calpain-inhibitors"},{"display_name":"calpain inhibition","id":"calpain-inhibition","score":0.4679,"url":"https://openalex.org/keywords/calpain-inhibition"},{"display_name":"calpain activation","id":"calpain-activation","score":0.4863,"url":"https://openalex.org/keywords/calpain-activation"},{"display_name":"calcium-dependent proteolysis","id":"calcium-dependent-proteolysis","score":0.4516,"url":"https://openalex.org/keywords/calcium-dependent-proteolysis"},{"display_name":"CAPN10","id":"capn10","score":0.3899,"url":"https://openalex.org/keywords/capn10"},{"display_name":"calcium-dependent protease","id":"calcium-dependent-protease","score":0.3539,"url":"https://openalex.org/keywords/calcium-dependent-protease"},{"display_name":"calpeptin","id":"calpeptin","score":0.3702,"url":"https://openalex.org/keywords/calpeptin"},{"display_name":"calpain substrates","id":"calpain-substrates","score":0.9142,"url":"https://openalex.org/keywords/calpain-substrates"},{"display_name":"calcium-dependent cysteine protease","id":"calcium-dependent-cysteine-protease","score":0.7344,"url":"https://openalex.org/keywords/calcium-dependent-cysteine-protease"},{"display_name":"calpain isoforms","id":"calpain-isoforms","score":0.9155,"url":"https://openalex.org/keywords/calpain-isoforms"},{"display_name":"calpain autolysis","id":"calpain-autolysis","score":0.74,"url":"https://openalex.org/keywords/calpain-autolysis"},{"display_name":"MDL28170","id":"mdl28170","score":0.2778,"url":"https://openalex.org/keywords/mdl28170"},{"display_name":"calpain activity","id":"calpain-activity","score":0.2598,"url":"https://openalex.org/keywords/calpain-activity"},{"display_name":"PD150606","id":"pd150606","score":0.5571,"url":"https://openalex.org/keywords/pd150606"},{"display_name":"calpain inhibitor I","id":"calpain-inhibitor-i","score":0.4266,"url":"https://openalex.org/keywords/calpain-inhibitor-i"},{"display_name":"calpain-mediated proteolysis","id":"calpain-mediated-proteolysis","score":0.377,"url":"https://openalex.org/keywords/calpain-mediated-proteolysis"},{"display_name":"calpain system","id":"calpain-system","score":0.2456,"url":"https://openalex.org/keywords/calpain-system"},{"display_name":"CAPNS1","id":"capns1","score":0.3466,"url":"https://openalex.org/keywords/capns1"},{"display_name":"calcium-dependent proteinase","id":"calcium-dependent-proteinase","score":0.336,"url":"https://openalex.org/keywords/calcium-dependent-proteinase"},{"display_name":"calpain proteolysis","id":"calpain-proteolysis","score":0.2976,"url":"https://openalex.org/keywords/calpain-proteolysis"},{"display_name":"spectrin breakdown products","id":"spectrin-breakdown-products","score":0.2478,"url":"https://openalex.org/keywords/spectrin-breakdown-products"}],"legacy_keywords":["Calpain","Cell Migration","Neurodegeneration","Proteolytic System","Apoptosis","Diabetes","Cancer","Mitochondria","Inhibitors","Cardiovascular Remodeling"],"openalex_id":"https://openalex.org/T13637","source_created_date":"2024-01-23T15:27:19","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T13637","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13637","works_count":5779,"label":"Calpain Protease Function and Regulation","provider":"openalex","revision":"3c4f84efe63541c0","taxonomy_revision":"f050b5d4780b1289","title":"Calpain Protease Function and Regulation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38293842646297167","address_version":"morton4x16-v1","coordinates":[1,13,1307,13637],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}