{"cited_by_count":160866,"description":"This cluster of papers focuses on the synthesis, stereocontrolled synthesis, and applications of \u00df-lactams, including their use as building blocks for various biologically active compounds such as anticancer agents and cholesterol absorption inhibitors. The research also delves into asymmetric catalysis, enantioselective synthesis, and the Kinugasa reaction for the production of these versatile compounds.","display_name":"Synthesis of \u03b2-Lactam Compounds","domain_id":"3","external_ids":{"openalex":"https://openalex.org/T13489","wikipedia":"https://en.wikipedia.org/wiki/Beta-Lactam_antibiotic"},"field_id":"16","id":"T13489","keywords":[{"display_name":"cephalosporin synthesis","id":"cephalosporin-synthesis","score":0.8536,"url":"https://openalex.org/keywords/cephalosporin-synthesis"},{"display_name":"\u03b2-lactam synthesis","id":"beta-lactam-synthesis","score":0.8317,"url":"https://openalex.org/keywords/beta-lactam-synthesis"},{"display_name":"azetidinones","id":"azetidinones","score":0.4493,"url":"https://openalex.org/keywords/azetidinones"},{"display_name":"lactam synthesis","id":"lactam-synthesis","score":0.2575,"url":"https://openalex.org/keywords/lactam-synthesis"},{"display_name":"azetidin-2-ones","id":"azetidin-2-ones","score":0.5794,"url":"https://openalex.org/keywords/azetidin-2-ones"},{"display_name":"carbapenem synthesis","id":"carbapenem-synthesis","score":0.9285,"url":"https://openalex.org/keywords/carbapenem-synthesis"},{"display_name":"penicillin biosynthesis","id":"penicillin-biosynthesis","score":0.2161,"url":"https://openalex.org/keywords/penicillin-biosynthesis"},{"display_name":"2-azetidinones","id":"2-azetidinones","score":0.508,"url":"https://openalex.org/keywords/2-azetidinones"},{"display_name":"penicillin derivatives","id":"penicillin-derivatives","score":0.2868,"url":"https://openalex.org/keywords/penicillin-derivatives"},{"display_name":"cephalosporin derivatives","id":"cephalosporin-derivatives","score":0.6056,"url":"https://openalex.org/keywords/cephalosporin-derivatives"},{"display_name":"Staudinger reaction","id":"staudinger-reaction","score":0.2111,"url":"https://openalex.org/keywords/staudinger-reaction"},{"display_name":"penicillin analogues","id":"penicillin-analogues","score":0.7085,"url":"https://openalex.org/keywords/penicillin-analogues"},{"display_name":"6-aminopenicillanic acid","id":"6-aminopenicillanic-acid","score":0.2161,"url":"https://openalex.org/keywords/6-aminopenicillanic-acid"},{"display_name":"azetidinone synthesis","id":"azetidinone-synthesis","score":0.5774,"url":"https://openalex.org/keywords/azetidinone-synthesis"},{"display_name":"1\u03b2-methylcarbapenems","id":"1beta-methylcarbapenems","score":0.9122,"url":"https://openalex.org/keywords/1beta-methylcarbapenems"},{"display_name":"thienamycin","id":"thienamycin","score":0.4652,"url":"https://openalex.org/keywords/thienamycin"},{"display_name":"\u03b2-lactam derivatives","id":"beta-lactam-derivatives","score":0.6776,"url":"https://openalex.org/keywords/beta-lactam-derivatives"},{"display_name":"penems","id":"penems","score":0.6033,"url":"https://openalex.org/keywords/penems"},{"display_name":"bicyclic \u03b2-lactams","id":"bicyclic-beta-lactams","score":0.8687,"url":"https://openalex.org/keywords/bicyclic-beta-lactams"},{"display_name":"monocyclic \u03b2-lactams","id":"monocyclic-beta-lactams","score":0.7067,"url":"https://openalex.org/keywords/monocyclic-beta-lactams"},{"display_name":"7-aminocephalosporanic acid","id":"7-aminocephalosporanic-acid","score":0.2773,"url":"https://openalex.org/keywords/7-aminocephalosporanic-acid"},{"display_name":"cephalosporin analogues","id":"cephalosporin-analogues","score":0.818,"url":"https://openalex.org/keywords/cephalosporin-analogues"},{"display_name":"penem antibiotics","id":"penem-antibiotics","score":0.3942,"url":"https://openalex.org/keywords/penem-antibiotics"},{"display_name":"spiro-\u03b2-lactams","id":"spiro-beta-lactams","score":0.7972,"url":"https://openalex.org/keywords/spiro-beta-lactams"},{"display_name":"azetidinone derivatives","id":"azetidinone-derivatives","score":0.4544,"url":"https://openalex.org/keywords/azetidinone-derivatives"}],"legacy_keywords":["Synthesis","Asymmetric Catalysis","Stereocontrolled Synthesis","Anticancer Agents","Cholesterol Absorption Inhibitors","Enantioselective Synthesis","Kinugasa Reaction","Azetidinones","Biological Evaluation","Antibacterial Agents"],"openalex_id":"https://openalex.org/T13489","source_created_date":"2024-01-23T15:27:18","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1605","url":"/topics/T13489","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13489","works_count":16559,"label":"Synthesis of \u03b2-Lactam Compounds","provider":"openalex","revision":"d343f8123f5e799b","taxonomy_revision":"f050b5d4780b1289","title":"Synthesis of \u03b2-Lactam Compounds","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38294068073727005","address_version":"morton4x16-v1","coordinates":[3,16,1605,13489],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}