{"cited_by_count":266603,"description":"This cluster of papers focuses on the regulation of bone mineralization, with a specific emphasis on the role of alkaline phosphatase, hypophosphatasia, matrix vesicles, and the molecular mechanisms involved in mineralization regulation. It also covers topics such as enzyme replacement therapy, biomineralization, and the involvement of PHOSPHO1 and osteopontin in bone mineralization.","display_name":"Alkaline Phosphatase Research Studies","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T13453","wikipedia":"https://en.wikipedia.org/wiki/Bone_mineralization"},"field_id":"27","id":"T13453","keywords":[{"display_name":"hypophosphatasia","id":"hypophosphatasia","score":0.6148,"url":"https://openalex.org/keywords/hypophosphatasia"},{"display_name":"tissue-nonspecific alkaline phosphatase","id":"tissue-nonspecific-alkaline-phosphatase","score":0.5994,"url":"https://openalex.org/keywords/tissue-nonspecific-alkaline-phosphatase"},{"display_name":"placental alkaline phosphatase","id":"placental-alkaline-phosphatase","score":0.335,"url":"https://openalex.org/keywords/placental-alkaline-phosphatase"},{"display_name":"intestinal alkaline phosphatase","id":"intestinal-alkaline-phosphatase","score":0.4246,"url":"https://openalex.org/keywords/intestinal-alkaline-phosphatase"},{"display_name":"matrix vesicles","id":"matrix-vesicles","score":0.3692,"url":"https://openalex.org/keywords/matrix-vesicles"},{"display_name":"ALPL gene","id":"alpl-gene","score":0.8731,"url":"https://openalex.org/keywords/alpl-gene"},{"display_name":"asfotase alfa","id":"asfotase-alfa","score":0.7675,"url":"https://openalex.org/keywords/asfotase-alfa"},{"display_name":"alkaline phosphatase isoenzymes","id":"alkaline-phosphatase-isoenzymes","score":0.6282,"url":"https://openalex.org/keywords/alkaline-phosphatase-isoenzymes"},{"display_name":"liver alkaline phosphatase","id":"liver-alkaline-phosphatase","score":0.7887,"url":"https://openalex.org/keywords/liver-alkaline-phosphatase"},{"display_name":"leukocyte alkaline phosphatase","id":"leukocyte-alkaline-phosphatase","score":0.3094,"url":"https://openalex.org/keywords/leukocyte-alkaline-phosphatase"},{"display_name":"infantile hypophosphatasia","id":"infantile-hypophosphatasia","score":0.8039,"url":"https://openalex.org/keywords/infantile-hypophosphatasia"},{"display_name":"alkaline phosphatase deficiency","id":"alkaline-phosphatase-deficiency","score":0.8115,"url":"https://openalex.org/keywords/alkaline-phosphatase-deficiency"},{"display_name":"bone mineralization disorders","id":"bone-mineralization-disorders","score":0.3354,"url":"https://openalex.org/keywords/bone-mineralization-disorders"},{"display_name":"serum phosphatase","id":"serum-phosphatase","score":0.397,"url":"https://openalex.org/keywords/serum-phosphatase"},{"display_name":"adult hypophosphatasia","id":"adult-hypophosphatasia","score":0.8724,"url":"https://openalex.org/keywords/adult-hypophosphatasia"},{"display_name":"adult-onset hypophosphatasia","id":"adult-onset-hypophosphatasia","score":0.8554,"url":"https://openalex.org/keywords/adult-onset-hypophosphatasia"},{"display_name":"perinatal hypophosphatasia","id":"perinatal-hypophosphatasia","score":0.8904,"url":"https://openalex.org/keywords/perinatal-hypophosphatasia"},{"display_name":"L-phenylalanine inhibition","id":"l-phenylalanine-inhibition","score":0.619,"url":"https://openalex.org/keywords/l-phenylalanine-inhibition"},{"display_name":"bone isoenzyme","id":"bone-isoenzyme","score":0.6028,"url":"https://openalex.org/keywords/bone-isoenzyme"},{"display_name":"human placental alkaline phosphatase","id":"human-placental-alkaline-phosphatase","score":0.3945,"url":"https://openalex.org/keywords/human-placental-alkaline-phosphatase"},{"display_name":"heat-stable alkaline phosphatase","id":"heat-stable-alkaline-phosphatase","score":0.4875,"url":"https://openalex.org/keywords/heat-stable-alkaline-phosphatase"},{"display_name":"alkaline phosphatase isozymes","id":"alkaline-phosphatase-isozymes","score":0.6628,"url":"https://openalex.org/keywords/alkaline-phosphatase-isozymes"},{"display_name":"ALPL gene mutations","id":"alpl-gene-mutations","score":0.9054,"url":"https://openalex.org/keywords/alpl-gene-mutations"},{"display_name":"hepatic alkaline phosphatase","id":"hepatic-alkaline-phosphatase","score":0.692,"url":"https://openalex.org/keywords/hepatic-alkaline-phosphatase"},{"display_name":"liver isoenzyme","id":"liver-isoenzyme","score":0.6526,"url":"https://openalex.org/keywords/liver-isoenzyme"}],"legacy_keywords":["Alkaline Phosphatase","Bone Mineralization","Hypophosphatasia","Matrix Vesicles","Osteoblasts","Enzyme Replacement Therapy","Mineralization Regulation","Biomineralization","PHOSPHO1","Osteopontin"],"openalex_id":"https://openalex.org/T13453","source_created_date":"2024-01-23T15:27:18","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2712","url":"/topics/T13453","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13453","works_count":16224,"label":"Alkaline Phosphatase Research Studies","provider":"openalex","revision":"1985c0c951b4739c","taxonomy_revision":"f050b5d4780b1289","title":"Alkaline Phosphatase Research Studies","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38360039769434410","address_version":"morton4x16-v1","coordinates":[4,27,2712,13453],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}