{"cited_by_count":725688,"description":"This cluster of papers focuses on the genetic, pharmacologic, and physiological aspects of lipid metabolism, particularly the role of ANGPTL3, lipoprotein lipase, and related proteins in regulating triglyceride levels and their implications for cardiovascular diseases such as familial chylomicronemia syndrome and atherosclerosis. It also explores the involvement of adipose tissue and metabolic syndrome in lipid regulation.","display_name":"Lipid metabolism and disorders","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T13430","wikipedia":"https://en.wikipedia.org/wiki/Lipid_metabolism"},"field_id":"27","id":"T13430","keywords":[{"display_name":"lipoprotein lipase","id":"lipoprotein-lipase","score":0.4321,"url":"https://openalex.org/keywords/lipoprotein-lipase"},{"display_name":"lipoprotein metabolism","id":"lipoprotein-metabolism","score":0.2259,"url":"https://openalex.org/keywords/lipoprotein-metabolism"},{"display_name":"triglyceride-rich lipoproteins","id":"triglyceride-rich-lipoproteins","score":0.3839,"url":"https://openalex.org/keywords/triglyceride-rich-lipoproteins"},{"display_name":"hepatic lipase","id":"hepatic-lipase","score":0.5053,"url":"https://openalex.org/keywords/hepatic-lipase"},{"display_name":"chylomicrons","id":"chylomicrons","score":0.4051,"url":"https://openalex.org/keywords/chylomicrons"},{"display_name":"postprandial lipemia","id":"postprandial-lipemia","score":0.2867,"url":"https://openalex.org/keywords/postprandial-lipemia"},{"display_name":"apolipoprotein C-III","id":"apolipoprotein-c-iii","score":0.3083,"url":"https://openalex.org/keywords/apolipoprotein-c-iii"},{"display_name":"triglyceride metabolism","id":"triglyceride-metabolism","score":0.398,"url":"https://openalex.org/keywords/triglyceride-metabolism"},{"display_name":"lipoprotein lipase deficiency","id":"lipoprotein-lipase-deficiency","score":0.7318,"url":"https://openalex.org/keywords/lipoprotein-lipase-deficiency"},{"display_name":"apolipoprotein C-II","id":"apolipoprotein-c-ii","score":0.4792,"url":"https://openalex.org/keywords/apolipoprotein-c-ii"},{"display_name":"severe hypertriglyceridemia","id":"severe-hypertriglyceridemia","score":0.5868,"url":"https://openalex.org/keywords/severe-hypertriglyceridemia"},{"display_name":"familial hypertriglyceridemia","id":"familial-hypertriglyceridemia","score":0.5692,"url":"https://openalex.org/keywords/familial-hypertriglyceridemia"},{"display_name":"APOA5","id":"apoa5","score":0.4471,"url":"https://openalex.org/keywords/apoa5"},{"display_name":"ANGPTL3","id":"angptl3","score":0.3875,"url":"https://openalex.org/keywords/angptl3"},{"display_name":"apolipoprotein B-48","id":"apolipoprotein-b48","score":0.4119,"url":"https://openalex.org/keywords/apolipoprotein-b48"},{"display_name":"chylomicron remnants","id":"chylomicron-remnants","score":0.4321,"url":"https://openalex.org/keywords/chylomicron-remnants"},{"display_name":"familial chylomicronemia syndrome","id":"familial-chylomicronemia-syndrome","score":0.8526,"url":"https://openalex.org/keywords/familial-chylomicronemia-syndrome"},{"display_name":"microsomal triglyceride transfer protein","id":"microsomal-triglyceride-transfer-protein","score":0.2863,"url":"https://openalex.org/keywords/microsomal-triglyceride-transfer-protein"},{"display_name":"abetalipoproteinemia","id":"abetalipoproteinemia","score":0.514,"url":"https://openalex.org/keywords/abetalipoproteinemia"},{"display_name":"familial combined hyperlipidemia","id":"familial-combined-hyperlipidemia","score":0.3118,"url":"https://openalex.org/keywords/familial-combined-hyperlipidemia"},{"display_name":"LPL gene","id":"lpl-gene","score":0.7279,"url":"https://openalex.org/keywords/lpl-gene"},{"display_name":"lipoprotein clearance","id":"lipoprotein-clearance","score":0.4048,"url":"https://openalex.org/keywords/lipoprotein-clearance"},{"display_name":"lipoprotein lipase activity","id":"lipoprotein-lipase-activity","score":0.6402,"url":"https://openalex.org/keywords/lipoprotein-lipase-activity"},{"display_name":"lipoprotein lipase gene","id":"lipoprotein-lipase-gene","score":0.7096,"url":"https://openalex.org/keywords/lipoprotein-lipase-gene"},{"display_name":"type III hyperlipoproteinemia","id":"type-iii-hyperlipoproteinemia","score":0.37,"url":"https://openalex.org/keywords/type-iii-hyperlipoproteinemia"}],"legacy_keywords":["ANGPTL3","Lipoprotein Lipase","Triglyceride Metabolism","Familial Chylomicronemia Syndrome","GPIHBP1","ANGPTL4","Adipose Tissue","Metabolic Syndrome","HDL Cholesterol","Atherosclerosis"],"openalex_id":"https://openalex.org/T13430","source_created_date":"2024-01-23T15:27:18","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2705","url":"/topics/T13430","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13430","works_count":36811,"label":"Lipid metabolism and disorders","provider":"openalex","revision":"934b286e9ff32b72","taxonomy_revision":"f050b5d4780b1289","title":"Lipid metabolism and disorders","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38360037765032358","address_version":"morton4x16-v1","coordinates":[4,27,2705,13430],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}