{"cited_by_count":119114,"description":"This cluster of papers focuses on the role of CCN proteins, particularly Connective Tissue Growth Factor (CTGF), in various signaling pathways such as TGF-\u00df and BMP, and their involvement in processes like angiogenesis, fibrosis, cell adhesion, regulation of gene expression, cancer progression, and wound healing.","display_name":"Connective Tissue Growth Factor Research","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13223","wikipedia":"https://en.wikipedia.org/wiki/CCN_protein"},"field_id":"13","id":"T13223","keywords":[{"display_name":"connective tissue growth factor","id":"connective-tissue-growth-factor","score":0.2062,"url":"https://openalex.org/keywords/connective-tissue-growth-factor"},{"display_name":"matricellular proteins","id":"matricellular-proteins","score":0.3297,"url":"https://openalex.org/keywords/matricellular-proteins"},{"display_name":"CYR61","id":"ccn1","score":0.2689,"url":"https://openalex.org/keywords/ccn1"},{"display_name":"CCN family","id":"ccn-family","score":0.7059,"url":"https://openalex.org/keywords/ccn-family"},{"display_name":"CCN3","id":"ccn3","score":0.4857,"url":"https://openalex.org/keywords/ccn3"},{"display_name":"CCN proteins","id":"ccn-proteins","score":0.759,"url":"https://openalex.org/keywords/ccn-proteins"},{"display_name":"NOV","id":"nov","score":0.3998,"url":"https://openalex.org/keywords/nov"},{"display_name":"CCN6","id":"ccn6","score":0.6681,"url":"https://openalex.org/keywords/ccn6"},{"display_name":"CCN5","id":"ccn5","score":0.5239,"url":"https://openalex.org/keywords/ccn5"},{"display_name":"CCN family proteins","id":"ccn-family-proteins","score":0.6928,"url":"https://openalex.org/keywords/ccn-family-proteins"},{"display_name":"CCN4","id":"ccn4","score":0.4746,"url":"https://openalex.org/keywords/ccn4"},{"display_name":"CTGF mRNA expression","id":"ctgf-mrna-expression","score":0.4429,"url":"https://openalex.org/keywords/ctgf-mrna-expression"},{"display_name":"WISP3","id":"wisp3","score":0.2799,"url":"https://openalex.org/keywords/wisp3"},{"display_name":"cysteine-rich protein 61","id":"cysteine-rich-protein-61","score":0.205,"url":"https://openalex.org/keywords/cysteine-rich-protein-61"}],"legacy_keywords":["Connective Tissue Growth Factor","CCN Family","Matricellular Proteins","Angiogenesis","Fibrosis","TGF-\u00df Signaling","Cell Adhesion","Regulation of Gene Expression","Cancer Progression","Wound Healing"],"openalex_id":"https://openalex.org/T13223","source_created_date":"2024-01-23T15:27:17","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T13223","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13223","works_count":4366,"label":"Connective Tissue Growth Factor Research","provider":"openalex","revision":"17112d0140a0b140","taxonomy_revision":"f050b5d4780b1289","title":"Connective Tissue Growth Factor Research","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285598334659211","address_version":"morton4x16-v1","coordinates":[1,13,1312,13223],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}