{"cited_by_count":146600,"description":"This cluster of papers focuses on the dynamics of protein-DNA interactions, including facilitated diffusion, stochastic resetting, search strategies, and L\u00e9vy walk patterns. It explores how proteins find their specific sites on DNA, the kinetics of target site localization, and the behavior of transcription factors at the single-molecule level in living cells.","display_name":"Diffusion and Search Dynamics","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13187","wikipedia":"https://en.wikipedia.org/wiki/Protein%E2%80%93DNA_interaction"},"field_id":"13","id":"T13187","keywords":[{"display_name":"DNA looping","id":"dna-looping","score":0.2115,"url":"https://openalex.org/keywords/dna-looping"},{"display_name":"nonspecific DNA binding","id":"nonspecific-dna-binding","score":0.2872,"url":"https://openalex.org/keywords/nonspecific-dna-binding"},{"display_name":"stochastic resetting","id":"stochastic-resetting","score":0.3598,"url":"https://openalex.org/keywords/stochastic-resetting"},{"display_name":"DNA sliding","id":"dna-sliding","score":0.4762,"url":"https://openalex.org/keywords/dna-sliding"},{"display_name":"protein-DNA search","id":"protein-dna-search","score":0.8937,"url":"https://openalex.org/keywords/protein-dna-search"},{"display_name":"protein-DNA binding kinetics","id":"protein-dna-binding-kinetics","score":0.3323,"url":"https://openalex.org/keywords/protein-dna-binding-kinetics"},{"display_name":"optimal resetting rate","id":"optimal-resetting-rate","score":0.6521,"url":"https://openalex.org/keywords/optimal-resetting-rate"},{"display_name":"tethered particle motion","id":"tethered-particle-motion","score":0.2324,"url":"https://openalex.org/keywords/tethered-particle-motion"},{"display_name":"diffusion-influenced reactions","id":"diffusion-influenced-reactions","score":0.3072,"url":"https://openalex.org/keywords/diffusion-influenced-reactions"},{"display_name":"discrete-state stochastic model","id":"discrete-state-stochastic-model","score":0.3728,"url":"https://openalex.org/keywords/discrete-state-stochastic-model"},{"display_name":"3D diffusion","id":"3d-diffusion","score":0.2308,"url":"https://openalex.org/keywords/3d-diffusion"},{"display_name":"DNA scanning","id":"dna-scanning","score":0.2807,"url":"https://openalex.org/keywords/dna-scanning"},{"display_name":"EcoRV restriction endonuclease","id":"ecorv-restriction-endonuclease","score":0.2238,"url":"https://openalex.org/keywords/ecorv-restriction-endonuclease"}],"legacy_keywords":["Protein-DNA Interaction","Facilitated Diffusion","Stochastic Resetting","Search Strategies","L\u00e9vy Walk Patterns","Target Localization","Transcription Factor Dynamics","DNA-Binding Proteins","Kinetics of Protein-DNA Interaction","Single-Molecule Measurements"],"openalex_id":"https://openalex.org/T13187","source_created_date":"2024-01-23T15:27:17","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T13187","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13187","works_count":5039,"label":"Diffusion and Search Dynamics","provider":"openalex","revision":"4543da62e620cb62","taxonomy_revision":"f050b5d4780b1289","title":"Diffusion and Search Dynamics","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285598326268555","address_version":"morton4x16-v1","coordinates":[1,13,1312,13187],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}