{"cited_by_count":178156,"description":"This cluster of papers focuses on proximity-dependent protein labeling techniques, such as BioID and TurboID, to identify protein-protein interactions and map spatial proteomes within living cells. The use of biotin, streptavidin, and avidin-based systems for enzymatic tagging and proximity labeling is a central theme in these studies, particularly in the context of investigating cellular interactomes and organelle-specific proteomes.","display_name":"Biotin and Related Studies","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13127","wikipedia":"https://en.wikipedia.org/wiki/Proximity_labeling"},"field_id":"13","id":"T13127","keywords":[{"display_name":"biotin","id":"biotin","score":0.2192,"url":"https://openalex.org/keywords/biotin"},{"display_name":"proximity labeling","id":"proximity-labeling","score":0.5041,"url":"https://openalex.org/keywords/proximity-labeling"},{"display_name":"biotin deficiency","id":"biotin-deficiency","score":0.4425,"url":"https://openalex.org/keywords/biotin-deficiency"},{"display_name":"biotin biosynthesis","id":"biotin-biosynthesis","score":0.4899,"url":"https://openalex.org/keywords/biotin-biosynthesis"},{"display_name":"avidin","id":"avidin","score":0.2632,"url":"https://openalex.org/keywords/avidin"},{"display_name":"biotin ligase","id":"biotin-protein-ligase","score":0.6099,"url":"https://openalex.org/keywords/biotin-protein-ligase"},{"display_name":"TurboID","id":"turboid","score":0.5589,"url":"https://openalex.org/keywords/turboid"},{"display_name":"biotin binding","id":"biotin-binding","score":0.4093,"url":"https://openalex.org/keywords/biotin-binding"},{"display_name":"BioID","id":"bioid","score":0.3319,"url":"https://openalex.org/keywords/bioid"},{"display_name":"proximity biotinylation","id":"proximity-dependent-biotinylation","score":0.499,"url":"https://openalex.org/keywords/proximity-dependent-biotinylation"},{"display_name":"biotin metabolism","id":"biotin-metabolism","score":0.3305,"url":"https://openalex.org/keywords/biotin-metabolism"},{"display_name":"desthiobiotin","id":"desthiobiotin","score":0.592,"url":"https://openalex.org/keywords/desthiobiotin"},{"display_name":"BirA","id":"bira","score":0.3571,"url":"https://openalex.org/keywords/bira"},{"display_name":"biotin-dependent enzymes","id":"biotin-dependent-enzymes","score":0.5218,"url":"https://openalex.org/keywords/biotin-dependent-enzymes"},{"display_name":"biotin-binding proteins","id":"biotin-binding-proteins","score":0.61,"url":"https://openalex.org/keywords/biotin-binding-proteins"},{"display_name":"dethiobiotin","id":"dethiobiotin","score":0.6669,"url":"https://openalex.org/keywords/dethiobiotin"},{"display_name":"APEX2","id":"apex2","score":0.3786,"url":"https://openalex.org/keywords/apex2"},{"display_name":"biotin transport","id":"biotin-transport","score":0.6685,"url":"https://openalex.org/keywords/biotin-transport"},{"display_name":"biotinylated proteins","id":"biotinylated-proteins","score":0.2582,"url":"https://openalex.org/keywords/biotinylated-proteins"},{"display_name":"biotin uptake","id":"biotin-uptake","score":0.6371,"url":"https://openalex.org/keywords/biotin-uptake"},{"display_name":"avidin-biotin complex","id":"avidin-biotin-complex","score":0.2839,"url":"https://openalex.org/keywords/avidin-biotin-complex"},{"display_name":"biocytin","id":"biocytin","score":0.2584,"url":"https://openalex.org/keywords/biocytin"},{"display_name":"biotinidase","id":"biotinidase","score":0.354,"url":"https://openalex.org/keywords/biotinidase"},{"display_name":"holocarboxylase synthetase","id":"holocarboxylase-synthetase","score":0.4265,"url":"https://openalex.org/keywords/holocarboxylase-synthetase"},{"display_name":"biotin vitamers","id":"biotin-vitamers","score":0.8967,"url":"https://openalex.org/keywords/biotin-vitamers"}],"legacy_keywords":["Proximity Labeling","Biotin","Enzymatic Tagging","Protein-Protein Interactions","Spatial Proteomic Mapping","Mitochondria","BioID","Streptavidin","Avidin","Cellular Interactome"],"openalex_id":"https://openalex.org/T13127","source_created_date":"2024-01-23T15:27:17","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T13127","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13127","works_count":8396,"label":"Biotin and Related Studies","provider":"openalex","revision":"f0a52c5c239eb47b","taxonomy_revision":"f050b5d4780b1289","title":"Biotin and Related Studies","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285596309088975","address_version":"morton4x16-v1","coordinates":[1,13,1307,13127],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}