{"cited_by_count":122306,"description":"This cluster of papers explores the role of sigma receptors, particularly the Sigma-1 receptor, in regulating cellular signaling, calcium signaling, cell survival, and their potential therapeutic implications in neuroprotection, neuropsychiatric disorders, cancer therapy, and neurodegenerative diseases.","display_name":"Pharmacological Receptor Mechanisms and Effects","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T13047","wikipedia":"https://en.wikipedia.org/wiki/Sigma-1_receptor"},"field_id":"13","id":"T13047","keywords":[{"display_name":"sigma-1 receptor","id":"sigma-1-receptor","score":0.6508,"url":"https://openalex.org/keywords/sigma-1-receptor"},{"display_name":"sigma receptors","id":"sigma-receptors","score":0.6552,"url":"https://openalex.org/keywords/sigma-receptors"},{"display_name":"sigma-2 receptor","id":"sigma-2-receptor","score":0.787,"url":"https://openalex.org/keywords/sigma-2-receptor"},{"display_name":"sigma receptor ligands","id":"sigma-receptor-ligands","score":0.8135,"url":"https://openalex.org/keywords/sigma-receptor-ligands"},{"display_name":"sigma-1 receptor agonist","id":"sigma-1-receptor-agonist","score":0.5356,"url":"https://openalex.org/keywords/sigma-1-receptor-agonist"},{"display_name":"sigma-1 receptor antagonists","id":"sigma-1-receptor-antagonists","score":0.72,"url":"https://openalex.org/keywords/sigma-1-receptor-antagonists"},{"display_name":"sigma receptor agonists","id":"sigma-receptor-agonists","score":0.8332,"url":"https://openalex.org/keywords/sigma-receptor-agonists"},{"display_name":"sigma receptor antagonists","id":"sigma-receptor-antagonists","score":0.8216,"url":"https://openalex.org/keywords/sigma-receptor-antagonists"},{"display_name":"SKF 10,047","id":"skf-10-047","score":0.5151,"url":"https://openalex.org/keywords/skf-10-047"},{"display_name":"NE-100","id":"ne-100","score":0.7652,"url":"https://openalex.org/keywords/ne-100"},{"display_name":"PRE-084","id":"pre-084","score":0.6694,"url":"https://openalex.org/keywords/pre-084"},{"display_name":"SA4503","id":"sa4503","score":0.8306,"url":"https://openalex.org/keywords/sa4503"},{"display_name":"sigma-1 receptor ligands","id":"sigma-1-receptor-ligands","score":0.776,"url":"https://openalex.org/keywords/sigma-1-receptor-ligands"},{"display_name":"BD1047","id":"bd1047","score":0.6493,"url":"https://openalex.org/keywords/bd1047"},{"display_name":"3-PPP","id":"3-ppp","score":0.3187,"url":"https://openalex.org/keywords/3-ppp"},{"display_name":"rimcazole","id":"rimcazole","score":0.6766,"url":"https://openalex.org/keywords/rimcazole"},{"display_name":"BMY 14802","id":"bmy-14802","score":0.6957,"url":"https://openalex.org/keywords/bmy-14802"},{"display_name":"TMEM97","id":"tmem97","score":0.4394,"url":"https://openalex.org/keywords/tmem97"},{"display_name":"1,3-di-o-tolylguanidine","id":"1-3-di-o-tolylguanidine","score":0.6402,"url":"https://openalex.org/keywords/1-3-di-o-tolylguanidine"},{"display_name":"DTG","id":"dtg","score":0.3457,"url":"https://openalex.org/keywords/dtg"},{"display_name":"N-allylnormetazocine","id":"n-allylnormetazocine","score":0.3912,"url":"https://openalex.org/keywords/n-allylnormetazocine"},{"display_name":"phencyclidine receptor","id":"phencyclidine-receptor","score":0.3342,"url":"https://openalex.org/keywords/phencyclidine-receptor"},{"display_name":"PCP receptor","id":"pcp-receptor","score":0.3495,"url":"https://openalex.org/keywords/pcp-receptor"},{"display_name":"siramesine","id":"siramesine","score":0.2541,"url":"https://openalex.org/keywords/siramesine"}],"legacy_keywords":["Sigma-1 Receptor","Chaperone","Cell Survival","Neuroprotection","ER-Mitochondrion Interface","Neuropsychiatric Disorders","Cancer Therapy","Antidepressants","Neurodegenerative Diseases","Calcium Signaling"],"openalex_id":"https://openalex.org/T13047","source_created_date":"2024-01-23T15:27:16","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T13047","works_api_url":"https://api.openalex.org/works?filter=topics.id:T13047","works_count":5083,"label":"Pharmacological Receptor Mechanisms and Effects","provider":"openalex","revision":"faf991779142b851","taxonomy_revision":"f050b5d4780b1289","title":"Pharmacological Receptor Mechanisms and Effects","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285564109662859","address_version":"morton4x16-v1","coordinates":[1,13,1312,13047],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}