{"cited_by_count":183908,"description":"This cluster of papers focuses on the neurotoxic effects of anesthetic agents, particularly during early development, leading to neuronal apoptosis, cognitive impairment, and altered synaptic plasticity. The research explores the long-term neurodevelopmental outcomes and potential learning disabilities associated with early exposure to general anesthetics, highlighting concerns about the impact on brain development.","display_name":"Anesthesia and Neurotoxicity Research","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12963","wikipedia":"https://en.wikipedia.org/wiki/Anesthetic_neurotoxicity"},"field_id":"28","id":"T12963","keywords":[{"display_name":"anesthetic neurotoxicity","id":"anesthetic-neurotoxicity","score":0.8481,"url":"https://openalex.org/keywords/anesthetic-neurotoxicity"},{"display_name":"perioperative neurocognitive disorder","id":"perioperative-neurocognitive-disorder","score":0.399,"url":"https://openalex.org/keywords/perioperative-neurocognitive-disorder"},{"display_name":"anesthetic neuroprotection","id":"anesthetic-neuroprotection","score":0.327,"url":"https://openalex.org/keywords/anesthetic-neuroprotection"},{"display_name":"anesthesia-induced cognitive impairment","id":"anesthesia-induced-cognitive-impairment","score":0.9214,"url":"https://openalex.org/keywords/anesthesia-induced-cognitive-impairment"},{"display_name":"anesthetic exposure","id":"anesthetic-exposure","score":0.4093,"url":"https://openalex.org/keywords/anesthetic-exposure"},{"display_name":"anesthesia exposure","id":"anesthesia-exposure","score":0.5232,"url":"https://openalex.org/keywords/anesthesia-exposure"},{"display_name":"postoperative neurocognitive disorder","id":"postoperative-neurocognitive-disorder","score":0.2808,"url":"https://openalex.org/keywords/postoperative-neurocognitive-disorder"},{"display_name":"tibial fracture surgery","id":"tibial-fracture-surgery","score":0.4761,"url":"https://openalex.org/keywords/tibial-fracture-surgery"},{"display_name":"repeated anesthesia","id":"repeated-anesthesia","score":0.2222,"url":"https://openalex.org/keywords/repeated-anesthesia"},{"display_name":"delayed neurocognitive recovery","id":"delayed-neurocognitive-recovery","score":0.2032,"url":"https://openalex.org/keywords/delayed-neurocognitive-recovery"},{"display_name":"perioperative cognitive dysfunction","id":"perioperative-cognitive-dysfunction","score":0.2216,"url":"https://openalex.org/keywords/perioperative-cognitive-dysfunction"},{"display_name":"early childhood surgery","id":"early-childhood-surgery","score":0.2121,"url":"https://openalex.org/keywords/early-childhood-surgery"},{"display_name":"step-through test","id":"step-through-test","score":0.2082,"url":"https://openalex.org/keywords/step-through-test"}],"legacy_keywords":["Anesthesia","Neurotoxicity","Brain Development","Cognitive Impairment","Neuronal Apoptosis","General Anesthetics","Neurodevelopmental Outcomes","Early Exposure","Learning Disabilities","Synaptic Plasticity"],"openalex_id":"https://openalex.org/T12963","source_created_date":"2024-01-23T15:27:16","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2806","url":"/topics/T12963","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12963","works_count":12178,"label":"Anesthesia and Neurotoxicity Research","provider":"openalex","revision":"2c980954f5bc1748","taxonomy_revision":"f050b5d4780b1289","title":"Anesthesia and Neurotoxicity Research","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351793511868105","address_version":"morton4x16-v1","coordinates":[1,28,2806,12963],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}