{"cited_by_count":78362,"description":"This cluster of papers focuses on the health effects associated with aristolochic acid, a compound found in certain Chinese herbs, and its link to nephropathy, urothelial carcinoma, and acute interstitial nephritis. It explores the renal toxicity, mutation signatures, DNA adduct formation, and the potential carcinogenicity of aristolochic acid in herbal remedies.","display_name":"Nephrotoxicity and Medicinal Plants","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12962","wikipedia":"https://en.wikipedia.org/wiki/Aristolochic_acid"},"field_id":"27","id":"T12962","keywords":[{"display_name":"aristolochic acid","id":"aristolochic-acid","score":0.5502,"url":"https://openalex.org/keywords/aristolochic-acid"},{"display_name":"aristolochic acid nephropathy","id":"aristolochic-acid-nephropathy","score":0.7379,"url":"https://openalex.org/keywords/aristolochic-acid-nephropathy"},{"display_name":"analgesic nephropathy","id":"analgesic-nephropathy","score":0.5899,"url":"https://openalex.org/keywords/analgesic-nephropathy"},{"display_name":"Balkan endemic nephropathy","id":"balkan-endemic-nephropathy","score":0.4625,"url":"https://openalex.org/keywords/balkan-endemic-nephropathy"},{"display_name":"aristolochic acid I","id":"aristolochic-acid-i","score":0.6796,"url":"https://openalex.org/keywords/aristolochic-acid-i"},{"display_name":"analgesic abuse","id":"analgesic-abuse","score":0.3416,"url":"https://openalex.org/keywords/analgesic-abuse"},{"display_name":"renal papillary necrosis","id":"renal-papillary-necrosis","score":0.2201,"url":"https://openalex.org/keywords/renal-papillary-necrosis"},{"display_name":"endemic nephropathy","id":"endemic-nephropathy","score":0.3611,"url":"https://openalex.org/keywords/endemic-nephropathy"},{"display_name":"aristolochic acid II","id":"aristolochic-acid-ii","score":0.6985,"url":"https://openalex.org/keywords/aristolochic-acid-ii"},{"display_name":"Aristolochia manshuriensis","id":"aristolochia-manshuriensis","score":0.3311,"url":"https://openalex.org/keywords/aristolochia-manshuriensis"},{"display_name":"analgesic-induced kidney injury","id":"analgesic-induced-kidney-injury","score":0.7951,"url":"https://openalex.org/keywords/analgesic-induced-kidney-injury"},{"display_name":"Aristolochia fangchi","id":"aristolochia-fangchi","score":0.5694,"url":"https://openalex.org/keywords/aristolochia-fangchi"},{"display_name":"aristolactams","id":"aristolactams","score":0.3943,"url":"https://openalex.org/keywords/aristolactams"},{"display_name":"analgesic nephrotoxicity","id":"analgesic-nephrotoxicity","score":0.5695,"url":"https://openalex.org/keywords/analgesic-nephrotoxicity"},{"display_name":"Balkan nephropathy","id":"balkan-nephropathy","score":0.5036,"url":"https://openalex.org/keywords/balkan-nephropathy"},{"display_name":"drug-induced kidney disease","id":"drug-induced-kidney-disease","score":0.2696,"url":"https://openalex.org/keywords/drug-induced-kidney-disease"},{"display_name":"aristolochic acid A","id":"aristolochic-acid-a","score":0.3301,"url":"https://openalex.org/keywords/aristolochic-acid-a"}],"legacy_keywords":["Aristolochic Acid","Nephropathy","Urothelial Carcinoma","Chinese Herb","Acute Interstitial Nephritis","Renal Toxicity","Mutation Signature","Environmental Carcinogen","DNA Adducts","Herbal Remedies"],"openalex_id":"https://openalex.org/T12962","source_created_date":"2024-01-23T15:27:16","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2741","url":"/topics/T12962","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12962","works_count":5442,"label":"Nephrotoxicity and Medicinal Plants","provider":"openalex","revision":"18e1d596597d40bd","taxonomy_revision":"f050b5d4780b1289","title":"Nephrotoxicity and Medicinal Plants","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351793444758950","address_version":"morton4x16-v1","coordinates":[4,27,2741,12962],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}