{"cited_by_count":83316,"description":"This cluster of papers focuses on the management, treatment, and complications of tumor lysis syndrome (TLS), a potentially life-threatening oncologic emergency characterized by metabolic disturbances. The papers cover various aspects including therapeutic strategies, classification, prophylaxis, risk evaluation, and the use of medications such as rasburicase and dapsone. Additionally, the cluster discusses related conditions like methemoglobinemia and hyperuricemia, particularly in pediatric and adult patients undergoing chemotherapy for hematologic malignancies.","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12845","wikipedia":"https://en.wikipedia.org/wiki/Tumor_lysis_syndrome"},"field_id":"27","id":"T12845","keywords":[{"display_name":"methemoglobinemia","id":"methemoglobinemia","score":0.5009,"url":"https://openalex.org/keywords/methemoglobinemia"},{"display_name":"tumor lysis syndrome","id":"tumor-lysis-syndrome","score":0.47,"url":"https://openalex.org/keywords/tumor-lysis-syndrome"},{"display_name":"oncologic emergencies","id":"oncologic-emergencies","score":0.3682,"url":"https://openalex.org/keywords/oncologic-emergencies"},{"display_name":"rasburicase","id":"rasburicase","score":0.6104,"url":"https://openalex.org/keywords/rasburicase"},{"display_name":"drug-induced methemoglobinemia","id":"drug-induced-methemoglobinemia","score":0.9418,"url":"https://openalex.org/keywords/drug-induced-methemoglobinemia"},{"display_name":"congenital methemoglobinemia","id":"congenital-methemoglobinemia","score":0.8728,"url":"https://openalex.org/keywords/congenital-methemoglobinemia"},{"display_name":"methemoglobin reduction","id":"methemoglobin-reduction","score":0.4895,"url":"https://openalex.org/keywords/methemoglobin-reduction"},{"display_name":"acquired methemoglobinemia","id":"acquired-methemoglobinemia","score":0.9495,"url":"https://openalex.org/keywords/acquired-methemoglobinemia"},{"display_name":"methemoglobin formation","id":"methemoglobin-formation","score":0.2187,"url":"https://openalex.org/keywords/methemoglobin-formation"},{"display_name":"co-oximetry","id":"co-oximetry","score":0.2409,"url":"https://openalex.org/keywords/co-oximetry"},{"display_name":"spontaneous tumor lysis syndrome","id":"spontaneous-tumor-lysis-syndrome","score":0.8498,"url":"https://openalex.org/keywords/spontaneous-tumor-lysis-syndrome"},{"display_name":"hereditary methemoglobinemia","id":"hereditary-methemoglobinemia","score":0.878,"url":"https://openalex.org/keywords/hereditary-methemoglobinemia"},{"display_name":"methemoglobin reductase","id":"methemoglobin-reductase","score":0.3841,"url":"https://openalex.org/keywords/methemoglobin-reductase"},{"display_name":"acute tumor lysis syndrome","id":"acute-tumor-lysis-syndrome","score":0.788,"url":"https://openalex.org/keywords/acute-tumor-lysis-syndrome"},{"display_name":"methemoglobinemia treatment","id":"methemoglobinemia-treatment","score":0.8477,"url":"https://openalex.org/keywords/methemoglobinemia-treatment"},{"display_name":"sulfhemoglobinemia","id":"sulfhemoglobinemia","score":0.5327,"url":"https://openalex.org/keywords/sulfhemoglobinemia"},{"display_name":"cytochrome b5 reductase deficiency","id":"cytochrome-b5-reductase-deficiency","score":0.7861,"url":"https://openalex.org/keywords/cytochrome-b5-reductase-deficiency"},{"display_name":"methemoglobin levels","id":"methemoglobin-levels","score":0.7318,"url":"https://openalex.org/keywords/methemoglobin-levels"},{"display_name":"hematologic emergencies","id":"hematologic-emergencies","score":0.2385,"url":"https://openalex.org/keywords/hematologic-emergencies"},{"display_name":"nitrobenzene poisoning","id":"nitrobenzene-poisoning","score":0.2754,"url":"https://openalex.org/keywords/nitrobenzene-poisoning"},{"display_name":"NADH-methemoglobin reductase","id":"nadh-methemoglobin-reductase","score":0.4818,"url":"https://openalex.org/keywords/nadh-methemoglobin-reductase"},{"display_name":"CYB5R3","id":"cyb5r3","score":0.2052,"url":"https://openalex.org/keywords/cyb5r3"}],"legacy_keywords":["Tumor Lysis Syndrome","Rasburicase","Methemoglobinemia","Hyperuricemia","Dapsone","Chemotherapy","Pediatric Oncology","Acute Kidney Injury","Oncologic Emergencies","Urate Oxidase"],"openalex_id":"https://openalex.org/T12845","source_created_date":"2024-01-23T15:27:15","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2740","url":"/topics/T12845","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12845","works_count":9876,"label":"Methemoglobinemia and Tumor Lysis Syndrome","provider":"openalex","revision":"edf683b28552807a","taxonomy_revision":"f050b5d4780b1289","title":"Methemoglobinemia and Tumor Lysis Syndrome","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351791297309994","address_version":"morton4x16-v1","coordinates":[4,27,2740,12845],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}