{"cited_by_count":470146,"description":"This cluster of papers focuses on the mechanisms and regulation of apoptotic cell clearance, including the role of CD47, phagocytosis, TAM receptors, efferocytosis, and the implications for cancer immunotherapy. It explores the involvement of various molecules and pathways in the recognition and removal of apoptotic cells by phagocytes, shedding light on potential therapeutic targets for immune-related diseases.","display_name":"Phagocytosis and Immune Regulation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12672","wikipedia":"https://en.wikipedia.org/wiki/Apoptotic_cell_clearance"},"field_id":"24","id":"T12672","keywords":[{"display_name":"efferocytosis","id":"efferocytosis","score":0.409,"url":"https://openalex.org/keywords/efferocytosis"},{"display_name":"CD47","id":"cd47","score":0.3574,"url":"https://openalex.org/keywords/cd47"},{"display_name":"SIRP\u03b1","id":"sirpalpha","score":0.4693,"url":"https://openalex.org/keywords/sirpalpha"},{"display_name":"apoptotic cells","id":"apoptotic-cells","score":0.2677,"url":"https://openalex.org/keywords/apoptotic-cells"},{"display_name":"MERTK","id":"mertk","score":0.2019,"url":"https://openalex.org/keywords/mertk"},{"display_name":"anti-CD47 antibody","id":"anti-cd47-antibody","score":0.5954,"url":"https://openalex.org/keywords/anti-cd47-antibody"},{"display_name":"CD47 blockade","id":"cd47-blockade","score":0.4835,"url":"https://openalex.org/keywords/cd47-blockade"},{"display_name":"phagocytosis of apoptotic cells","id":"phagocytosis-of-apoptotic-cells","score":0.3996,"url":"https://openalex.org/keywords/phagocytosis-of-apoptotic-cells"},{"display_name":"TAM receptors","id":"tam-receptors","score":0.2422,"url":"https://openalex.org/keywords/tam-receptors"},{"display_name":"eat-me signals","id":"eat-me-signals","score":0.5976,"url":"https://openalex.org/keywords/eat-me-signals"},{"display_name":"apoptotic neutrophils","id":"apoptotic-neutrophils","score":0.5193,"url":"https://openalex.org/keywords/apoptotic-neutrophils"},{"display_name":"don't eat me signal","id":"don-t-eat-me-signal","score":0.6013,"url":"https://openalex.org/keywords/don-t-eat-me-signal"},{"display_name":"phosphatidylserine receptor","id":"phosphatidylserine-receptor","score":0.4358,"url":"https://openalex.org/keywords/phosphatidylserine-receptor"},{"display_name":"innate immune checkpoint","id":"innate-immune-checkpoint","score":0.4693,"url":"https://openalex.org/keywords/innate-immune-checkpoint"},{"display_name":"phagocytic receptors","id":"phagocytic-receptors","score":0.3484,"url":"https://openalex.org/keywords/phagocytic-receptors"},{"display_name":"CD47-SIRP\u03b1 axis","id":"cd47-sirpalpha-axis","score":0.6528,"url":"https://openalex.org/keywords/cd47-sirpalpha-axis"},{"display_name":"macrophage efferocytosis","id":"macrophage-efferocytosis","score":0.3265,"url":"https://openalex.org/keywords/macrophage-efferocytosis"},{"display_name":"phagosome formation","id":"phagosome-formation","score":0.2036,"url":"https://openalex.org/keywords/phagosome-formation"},{"display_name":"apoptotic cell recognition","id":"apoptotic-cell-recognition","score":0.5315,"url":"https://openalex.org/keywords/apoptotic-cell-recognition"},{"display_name":"apoptotic cell engulfment","id":"apoptotic-cell-engulfment","score":0.53,"url":"https://openalex.org/keywords/apoptotic-cell-engulfment"},{"display_name":"neutrophil clearance","id":"neutrophil-clearance","score":0.216,"url":"https://openalex.org/keywords/neutrophil-clearance"},{"display_name":"anti-CD47 monoclonal antibody","id":"anti-cd47-monoclonal-antibody","score":0.5634,"url":"https://openalex.org/keywords/anti-cd47-monoclonal-antibody"},{"display_name":"CD47-SIRP\u03b1 interaction","id":"cd47-sirpalpha-interaction","score":0.7169,"url":"https://openalex.org/keywords/cd47-sirpalpha-interaction"},{"display_name":"tumor phagocytosis","id":"tumor-phagocytosis","score":0.4335,"url":"https://openalex.org/keywords/tumor-phagocytosis"},{"display_name":"find-me signals","id":"find-me-signals","score":0.5944,"url":"https://openalex.org/keywords/find-me-signals"}],"legacy_keywords":["CD47","apoptotic cells","phagocytosis","immune regulation","clearance mechanisms","TAM receptors","efferocytosis","cancer immunotherapy","phosphatidylserine","macrophages"],"openalex_id":"https://openalex.org/T12672","source_created_date":"2024-01-23T15:27:15","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T12672","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12672","works_count":16621,"label":"Phagocytosis and Immune Regulation","provider":"openalex","revision":"623b2041722fb985","taxonomy_revision":"f050b5d4780b1289","title":"Phagocytosis and Immune Regulation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351019335360581","address_version":"morton4x16-v1","coordinates":[1,24,2403,12672],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}