{"cited_by_count":216163,"description":"This cluster of papers focuses on xenotransplantation, particularly the use of pigs as organ donors for human transplantation. It covers topics such as genetic modification of pigs, porcine endogenous retroviruses, immunological barriers, xenograft rejection, and the potential applications in clinical xenotransplantation and biomedical research.","display_name":"Xenotransplantation and immune response","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12654","wikipedia":"https://en.wikipedia.org/wiki/Xenotransplantation"},"field_id":"27","id":"T12654","keywords":[{"display_name":"xenotransplantation","id":"xenotransplantation","score":0.3406,"url":"https://openalex.org/keywords/xenotransplantation"},{"display_name":"xenograft rejection","id":"xenograft-rejection","score":0.6809,"url":"https://openalex.org/keywords/xenograft-rejection"},{"display_name":"hyperacute rejection","id":"hyperacute-rejection","score":0.5215,"url":"https://openalex.org/keywords/hyperacute-rejection"},{"display_name":"porcine endogenous retroviruses","id":"porcine-endogenous-retrovirus","score":0.8709,"url":"https://openalex.org/keywords/porcine-endogenous-retrovirus"},{"display_name":"transgenic pigs","id":"transgenic-pigs","score":0.3351,"url":"https://openalex.org/keywords/transgenic-pigs"},{"display_name":"pig-to-human xenotransplantation","id":"pig-to-human-xenotransplantation","score":0.8112,"url":"https://openalex.org/keywords/pig-to-human-xenotransplantation"},{"display_name":"genetically modified pigs","id":"genetically-modified-pigs","score":0.6859,"url":"https://openalex.org/keywords/genetically-modified-pigs"},{"display_name":"xenograft survival","id":"xenograft-survival","score":0.5224,"url":"https://openalex.org/keywords/xenograft-survival"},{"display_name":"cardiac xenotransplantation","id":"cardiac-xenotransplantation","score":0.8954,"url":"https://openalex.org/keywords/cardiac-xenotransplantation"},{"display_name":"xenotransplantation safety","id":"xenotransplantation-safety","score":0.8285,"url":"https://openalex.org/keywords/xenotransplantation-safety"},{"display_name":"islet xenotransplantation","id":"islet-xenotransplantation","score":0.5127,"url":"https://openalex.org/keywords/islet-xenotransplantation"},{"display_name":"pig-to-primate xenotransplantation","id":"pig-to-primate-xenotransplantation","score":0.9434,"url":"https://openalex.org/keywords/pig-to-primate-xenotransplantation"},{"display_name":"alpha-1,3-galactosyltransferase","id":"alpha-1-3-galactosyltransferase","score":0.3996,"url":"https://openalex.org/keywords/alpha-1-3-galactosyltransferase"},{"display_name":"kidney xenotransplantation","id":"kidney-xenotransplantation","score":0.9249,"url":"https://openalex.org/keywords/kidney-xenotransplantation"},{"display_name":"alpha-gal epitope","id":"alpha-gal-epitope","score":0.3578,"url":"https://openalex.org/keywords/alpha-gal-epitope"},{"display_name":"xenoreactive antibodies","id":"xenoreactive-antibodies","score":0.8692,"url":"https://openalex.org/keywords/xenoreactive-antibodies"},{"display_name":"porcine endothelial cells","id":"porcine-endothelial-cells","score":0.4669,"url":"https://openalex.org/keywords/porcine-endothelial-cells"},{"display_name":"xenoantigens","id":"xenoantigens","score":0.5478,"url":"https://openalex.org/keywords/xenoantigens"},{"display_name":"xenotransplantation immunology","id":"xenotransplantation-immunology","score":0.8941,"url":"https://openalex.org/keywords/xenotransplantation-immunology"},{"display_name":"porcine islets","id":"porcine-islets","score":0.2786,"url":"https://openalex.org/keywords/porcine-islets"},{"display_name":"liver xenotransplantation","id":"liver-xenotransplantation","score":0.8709,"url":"https://openalex.org/keywords/liver-xenotransplantation"},{"display_name":"animal-to-human organ transplantation","id":"animal-to-human-organ-transplantation","score":0.9078,"url":"https://openalex.org/keywords/animal-to-human-organ-transplantation"},{"display_name":"xenotransplantation ethics","id":"xenotransplantation-ethics","score":0.8307,"url":"https://openalex.org/keywords/xenotransplantation-ethics"},{"display_name":"acute vascular rejection","id":"acute-vascular-rejection","score":0.4284,"url":"https://openalex.org/keywords/acute-vascular-rejection"},{"display_name":"anti-Gal antibodies","id":"anti-gal-antibodies","score":0.4591,"url":"https://openalex.org/keywords/anti-gal-antibodies"}],"legacy_keywords":["Xenotransplantation","Pig-to-Human Transplantation","Genetic Modification of Pigs","Porcine Endogenous Retroviruses","Immunological Barriers","Xenograft Rejection","Transgenic Pigs","Clinical Xenotransplantation","Graft Survival","Biomedical Research"],"openalex_id":"https://openalex.org/T12654","source_created_date":"2024-01-23T15:27:15","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2746","url":"/topics/T12654","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12654","works_count":15697,"label":"Xenotransplantation and immune response","provider":"openalex","revision":"a5e454a67e656277","taxonomy_revision":"f050b5d4780b1289","title":"Xenotransplantation and immune response","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351276035467746","address_version":"morton4x16-v1","coordinates":[4,27,2746,12654],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}