{"cited_by_count":144058,"description":"This cluster of papers explores the advances in aryne chemistry and its applications in organic synthesis, including transition-metal-free reactions, natural product total synthesis, multicomponent coupling, and the use of arynes in Diels\u2013Alder reactions. The research also delves into the synthesis of heterocycles, regioselectivities of aryne reactions, and the role of arynes in the construction of polycyclic aromatic compounds.","display_name":"Cyclization and Aryne Chemistry","domain_id":"3","external_ids":{"openalex":"https://openalex.org/T12653","wikipedia":"https://en.wikipedia.org/wiki/Aryne_chemistry"},"field_id":"16","id":"T12653","keywords":[{"display_name":"benzyne","id":"benzyne","score":0.6008,"url":"https://openalex.org/keywords/benzyne"},{"display_name":"arynes","id":"arynes","score":0.7146,"url":"https://openalex.org/keywords/arynes"},{"display_name":"enediynes","id":"enediynes","score":0.3177,"url":"https://openalex.org/keywords/enediynes"},{"display_name":"anthracyclinones","id":"anthracyclinones","score":0.5736,"url":"https://openalex.org/keywords/anthracyclinones"},{"display_name":"cycloaromatization","id":"cycloaromatization","score":0.3684,"url":"https://openalex.org/keywords/cycloaromatization"},{"display_name":"Bergman cyclization","id":"bergman-cyclization","score":0.4022,"url":"https://openalex.org/keywords/bergman-cyclization"},{"display_name":"aryne intermediates","id":"aryne-intermediates","score":0.6151,"url":"https://openalex.org/keywords/aryne-intermediates"},{"display_name":"aryne chemistry","id":"aryne-chemistry","score":0.8328,"url":"https://openalex.org/keywords/aryne-chemistry"},{"display_name":"aryne synthesis","id":"aryne-synthesis","score":0.3187,"url":"https://openalex.org/keywords/aryne-synthesis"},{"display_name":"aryne precursors","id":"aryne-precursors","score":0.7805,"url":"https://openalex.org/keywords/aryne-precursors"},{"display_name":"enediyne antibiotics","id":"enediyne-antibiotics","score":0.2907,"url":"https://openalex.org/keywords/enediyne-antibiotics"},{"display_name":"hexadehydro-Diels-Alder reaction","id":"hexadehydro-diels-alder-reaction","score":0.7306,"url":"https://openalex.org/keywords/hexadehydro-diels-alder-reaction"},{"display_name":"aryne insertion","id":"aryne-insertion","score":0.9027,"url":"https://openalex.org/keywords/aryne-insertion"},{"display_name":"benzyne intermediates","id":"benzyne-intermediates","score":0.376,"url":"https://openalex.org/keywords/benzyne-intermediates"},{"display_name":"benzyne precursors","id":"benzyne-precursors","score":0.7493,"url":"https://openalex.org/keywords/benzyne-precursors"},{"display_name":"daunomycinone","id":"daunomycinone","score":0.2446,"url":"https://openalex.org/keywords/daunomycinone"},{"display_name":"dehydrobenzene","id":"dehydrobenzene","score":0.2348,"url":"https://openalex.org/keywords/dehydrobenzene"},{"display_name":"enyne-allenes","id":"enyne-allenes","score":0.5431,"url":"https://openalex.org/keywords/enyne-allenes"},{"display_name":"dynemicin A","id":"dynemicin-a","score":0.3625,"url":"https://openalex.org/keywords/dynemicin-a"},{"display_name":"anthracycline synthesis","id":"anthracycline-synthesis","score":0.4929,"url":"https://openalex.org/keywords/anthracycline-synthesis"},{"display_name":"enediyne synthesis","id":"enediyne-synthesis","score":0.3704,"url":"https://openalex.org/keywords/enediyne-synthesis"},{"display_name":"esperamicin","id":"esperamicin","score":0.2833,"url":"https://openalex.org/keywords/esperamicin"},{"display_name":"neocarzinostatin chromophore","id":"neocarzinostatin-chromophore","score":0.294,"url":"https://openalex.org/keywords/neocarzinostatin-chromophore"},{"display_name":"kedarcidin","id":"kedarcidin","score":0.2774,"url":"https://openalex.org/keywords/kedarcidin"}],"legacy_keywords":["Arynes","Organic Synthesis","Transition-Metal-Free Reactions","Natural Product Total Synthesis","Multicomponent Coupling","Diels\u2013Alder Reactions","Benzynes","Heterocycles","Regioselectivities","Polycyclic Aromatic Compounds"],"openalex_id":"https://openalex.org/T12653","source_created_date":"2024-01-23T15:27:15","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1605","url":"/topics/T12653","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12653","works_count":9665,"label":"Cyclization and Aryne Chemistry","provider":"openalex","revision":"10f6f2957d6bcc59","taxonomy_revision":"f050b5d4780b1289","title":"Cyclization and Aryne Chemistry","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285304326687773","address_version":"morton4x16-v1","coordinates":[3,16,1605,12653],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}