{"cited_by_count":294316,"description":"This cluster of papers focuses on the pharmacology, synthesis, and effects of kratom alkaloids, particularly those derived from Mitragyna speciosa. It covers topics such as opioid withdrawal, neuropharmacological effects, total synthesis of alkaloids, traditional medicine usage, and toxicological studies.","display_name":"Alkaloids: synthesis and pharmacology","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12649","wikipedia":"https://en.wikipedia.org/wiki/Mitragyna_speciosa"},"field_id":"30","id":"T12649","keywords":[{"display_name":"plant alkaloids","id":"plant-alkaloids","score":0.2038,"url":"https://openalex.org/keywords/plant-alkaloids"},{"display_name":"Mitragyna speciosa","id":"kratom","score":0.5551,"url":"https://openalex.org/keywords/kratom"},{"display_name":"alkaloid isolation","id":"alkaloid-isolation","score":0.2046,"url":"https://openalex.org/keywords/alkaloid-isolation"},{"display_name":"alkaloid chemistry","id":"alkaloid-chemistry","score":0.5092,"url":"https://openalex.org/keywords/alkaloid-chemistry"},{"display_name":"opium alkaloids","id":"opium-alkaloids","score":0.3433,"url":"https://openalex.org/keywords/opium-alkaloids"},{"display_name":"mitragynine","id":"mitragynine","score":0.6823,"url":"https://openalex.org/keywords/mitragynine"},{"display_name":"alkaloid structure","id":"alkaloid-structure","score":0.3284,"url":"https://openalex.org/keywords/alkaloid-structure"},{"display_name":"morphine derivatives","id":"morphine-derivatives","score":0.3352,"url":"https://openalex.org/keywords/morphine-derivatives"},{"display_name":"monoterpene indole alkaloids","id":"monoterpene-indole-alkaloids","score":0.2057,"url":"https://openalex.org/keywords/monoterpene-indole-alkaloids"},{"display_name":"thebaine","id":"thebaine","score":0.272,"url":"https://openalex.org/keywords/thebaine"},{"display_name":"opioid alkaloids","id":"opioid-alkaloids","score":0.4347,"url":"https://openalex.org/keywords/opioid-alkaloids"},{"display_name":"new alkaloids","id":"new-alkaloids","score":0.2274,"url":"https://openalex.org/keywords/new-alkaloids"},{"display_name":"quinine alkaloids","id":"quinine-alkaloids","score":0.4076,"url":"https://openalex.org/keywords/quinine-alkaloids"},{"display_name":"morphine alkaloids","id":"morphine-alkaloids","score":0.445,"url":"https://openalex.org/keywords/morphine-alkaloids"},{"display_name":"Rauwolfia alkaloids","id":"rauwolfia-alkaloids","score":0.3194,"url":"https://openalex.org/keywords/rauwolfia-alkaloids"},{"display_name":"7-hydroxymitragynine","id":"7-hydroxymitragynine","score":0.8129,"url":"https://openalex.org/keywords/7-hydroxymitragynine"},{"display_name":"bisindole alkaloids","id":"bisindole-alkaloids","score":0.3209,"url":"https://openalex.org/keywords/bisindole-alkaloids"},{"display_name":"Strychnos alkaloids","id":"strychnos-alkaloids","score":0.4651,"url":"https://openalex.org/keywords/strychnos-alkaloids"},{"display_name":"ibogaine","id":"ibogaine","score":0.2279,"url":"https://openalex.org/keywords/ibogaine"},{"display_name":"ajmaline","id":"ajmaline","score":0.2053,"url":"https://openalex.org/keywords/ajmaline"},{"display_name":"morphinan derivatives","id":"morphinan-derivatives","score":0.3056,"url":"https://openalex.org/keywords/morphinan-derivatives"},{"display_name":"alkaloid taxonomy","id":"alkaloid-taxonomy","score":0.4972,"url":"https://openalex.org/keywords/alkaloid-taxonomy"},{"display_name":"kratom alkaloids","id":"kratom-alkaloids","score":0.8385,"url":"https://openalex.org/keywords/kratom-alkaloids"},{"display_name":"salvinorin A","id":"salvinorin-a","score":0.2304,"url":"https://openalex.org/keywords/salvinorin-a"},{"display_name":"alkaloid structure elucidation","id":"alkaloid-structure-elucidation","score":0.2396,"url":"https://openalex.org/keywords/alkaloid-structure-elucidation"}],"legacy_keywords":["Kratom","Alkaloids","Mitragyna Speciosa","Opioid Withdrawal","Indole Alkaloids","Total Synthesis","Pharmacological Effects","Traditional Medicine","Neuropharmacology","Toxicology"],"openalex_id":"https://openalex.org/T12649","source_created_date":"2024-01-23T15:27:15","source_updated_date":"2026-10-17T03:02:00","subfield_id":"3004","url":"/topics/T12649","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12649","works_count":36831,"label":"Alkaloids: synthesis and pharmacology","provider":"openalex","revision":"14abcf05c709242a","taxonomy_revision":"f050b5d4780b1289","title":"Alkaloids: synthesis and pharmacology","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351293215335977","address_version":"morton4x16-v1","coordinates":[1,30,3004,12649],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}