{"cited_by_count":687086,"description":"This cluster of papers focuses on the prediction of peptide-major histocompatibility complex (MHC) binding affinity, epitope prediction, and immunoinformatics for vaccine design. It covers topics such as antigen presentation, HLA class I and II molecules, bioinformatics tools for epitope prediction, T-cell and B-cell epitopes, and proteasomal cleavage.","display_name":"vaccines and immunoinformatics approaches","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12576","wikipedia":"https://en.wikipedia.org/wiki/Peptide-MHC_binding"},"field_id":"13","id":"T12576","keywords":[{"display_name":"T cell epitopes","id":"t-cell-epitopes","score":0.3489,"url":"https://openalex.org/keywords/t-cell-epitopes"},{"display_name":"epitope prediction","id":"epitope-prediction","score":0.7284,"url":"https://openalex.org/keywords/epitope-prediction"},{"display_name":"B-cell epitopes","id":"b-cell-epitopes","score":0.4447,"url":"https://openalex.org/keywords/b-cell-epitopes"},{"display_name":"vaccine design","id":"vaccine-design","score":0.2936,"url":"https://openalex.org/keywords/vaccine-design"},{"display_name":"multi-epitope vaccine","id":"multiepitope-vaccine","score":0.7507,"url":"https://openalex.org/keywords/multiepitope-vaccine"},{"display_name":"immunoinformatics","id":"immunoinformatics","score":0.7047,"url":"https://openalex.org/keywords/immunoinformatics"},{"display_name":"CTL epitopes","id":"ctl-epitopes","score":0.4299,"url":"https://openalex.org/keywords/ctl-epitopes"},{"display_name":"peptide binding","id":"peptide-binding","score":0.2739,"url":"https://openalex.org/keywords/peptide-binding"},{"display_name":"peptide-MHC complex","id":"peptide-mhc-complex","score":0.3782,"url":"https://openalex.org/keywords/peptide-mhc-complex"},{"display_name":"reverse vaccinology","id":"reverse-vaccinology","score":0.6902,"url":"https://openalex.org/keywords/reverse-vaccinology"},{"display_name":"HLA-A*0201","id":"hla-a-0201","score":0.2236,"url":"https://openalex.org/keywords/hla-a-0201"},{"display_name":"peptide-MHC binding","id":"peptide-mhc-binding","score":0.5917,"url":"https://openalex.org/keywords/peptide-mhc-binding"},{"display_name":"peptide presentation","id":"peptide-presentation","score":0.3877,"url":"https://openalex.org/keywords/peptide-presentation"},{"display_name":"B-cell epitope prediction","id":"b-cell-epitope-prediction","score":0.7169,"url":"https://openalex.org/keywords/b-cell-epitope-prediction"},{"display_name":"epitope-based vaccine","id":"epitope-based-vaccine","score":0.5022,"url":"https://openalex.org/keywords/epitope-based-vaccine"},{"display_name":"MHC class I binding","id":"mhc-class-i-binding","score":0.5479,"url":"https://openalex.org/keywords/mhc-class-i-binding"},{"display_name":"peptide binding prediction","id":"peptide-binding-prediction","score":0.7755,"url":"https://openalex.org/keywords/peptide-binding-prediction"},{"display_name":"T-cell epitope prediction","id":"t-cell-epitope-prediction","score":0.8067,"url":"https://openalex.org/keywords/t-cell-epitope-prediction"},{"display_name":"peptide binding affinity","id":"peptide-binding-affinity","score":0.2702,"url":"https://openalex.org/keywords/peptide-binding-affinity"},{"display_name":"conserved epitopes","id":"conserved-epitopes","score":0.2288,"url":"https://openalex.org/keywords/conserved-epitopes"},{"display_name":"helper T cell epitopes","id":"helper-t-cell-epitopes","score":0.5928,"url":"https://openalex.org/keywords/helper-t-cell-epitopes"},{"display_name":"MHC class II binding","id":"mhc-class-ii-binding","score":0.4429,"url":"https://openalex.org/keywords/mhc-class-ii-binding"},{"display_name":"immunogenicity prediction","id":"immunogenicity-prediction","score":0.6253,"url":"https://openalex.org/keywords/immunogenicity-prediction"},{"display_name":"MHC binding prediction","id":"peptide-mhc-binding-prediction","score":0.7523,"url":"https://openalex.org/keywords/peptide-mhc-binding-prediction"},{"display_name":"MHC class I epitopes","id":"mhc-class-i-epitopes","score":0.4266,"url":"https://openalex.org/keywords/mhc-class-i-epitopes"}],"legacy_keywords":["Peptide-MHC Binding","Epitope Prediction","Immunoinformatics","Vaccine Design","Antigen Presentation","HLA Class I and II","Bioinformatics Tools","T-Cell Epitopes","B-Cell Epitopes","Proteasomal Cleavage"],"openalex_id":"https://openalex.org/T12576","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T12576","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12576","works_count":33087,"label":"vaccines and immunoinformatics approaches","provider":"openalex","revision":"80844c002716c423","taxonomy_revision":"f050b5d4780b1289","title":"vaccines and immunoinformatics approaches","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285046431359491","address_version":"morton4x16-v1","coordinates":[1,13,1312,12576],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}