{"cited_by_count":323846,"description":"This cluster of papers explores the cellular response to osmotic stress, with a focus on the role of aldose reductase, taurine, and the aldo-keto reductase superfamily in conditions such as diabetes, inflammation, and oxidative stress. It also delves into the implications for mitochondrial function, neuroprotection, and cardiovascular health.","display_name":"Aldose Reductase and Taurine","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12533","wikipedia":"https://en.wikipedia.org/wiki/Osmotic_stress"},"field_id":"13","id":"T12533","keywords":[{"display_name":"taurine","id":"taurine","score":0.3072,"url":"https://openalex.org/keywords/taurine"},{"display_name":"aldose reductase","id":"aldose-reductase","score":0.541,"url":"https://openalex.org/keywords/aldose-reductase"},{"display_name":"aldose reductase inhibitors","id":"aldose-reductase-inhibitors","score":0.7376,"url":"https://openalex.org/keywords/aldose-reductase-inhibitors"},{"display_name":"polyol pathway","id":"polyol-pathway","score":0.44,"url":"https://openalex.org/keywords/polyol-pathway"},{"display_name":"aldose reductase inhibition","id":"aldose-reductase-inhibition","score":0.5001,"url":"https://openalex.org/keywords/aldose-reductase-inhibition"},{"display_name":"taurine supplementation","id":"taurine-supplementation","score":0.4947,"url":"https://openalex.org/keywords/taurine-supplementation"},{"display_name":"sorbinil","id":"sorbinil","score":0.772,"url":"https://openalex.org/keywords/sorbinil"},{"display_name":"sorbitol accumulation","id":"sorbitol-accumulation","score":0.6309,"url":"https://openalex.org/keywords/sorbitol-accumulation"},{"display_name":"taurine transporter","id":"taurine-transporter","score":0.5681,"url":"https://openalex.org/keywords/taurine-transporter"},{"display_name":"aldehyde reductase","id":"aldehyde-reductase","score":0.4239,"url":"https://openalex.org/keywords/aldehyde-reductase"},{"display_name":"aldo-keto reductase","id":"aldo-keto-reductase","score":0.2417,"url":"https://openalex.org/keywords/aldo-keto-reductase"},{"display_name":"taurine deficiency","id":"taurine-deficiency","score":0.6846,"url":"https://openalex.org/keywords/taurine-deficiency"},{"display_name":"taurine transport","id":"taurine-transport","score":0.7618,"url":"https://openalex.org/keywords/taurine-transport"},{"display_name":"taurine biosynthesis","id":"taurine-synthesis","score":0.6156,"url":"https://openalex.org/keywords/taurine-synthesis"},{"display_name":"taurine uptake","id":"taurine-uptake","score":0.7895,"url":"https://openalex.org/keywords/taurine-uptake"},{"display_name":"hypotaurine","id":"hypotaurine","score":0.2411,"url":"https://openalex.org/keywords/hypotaurine"},{"display_name":"epalrestat","id":"epalrestat","score":0.3667,"url":"https://openalex.org/keywords/epalrestat"},{"display_name":"taurine metabolism","id":"taurine-metabolism","score":0.3921,"url":"https://openalex.org/keywords/taurine-metabolism"},{"display_name":"AKR1B10","id":"akr1b10","score":0.2627,"url":"https://openalex.org/keywords/akr1b10"},{"display_name":"taurine release","id":"taurine-release","score":0.6227,"url":"https://openalex.org/keywords/taurine-release"},{"display_name":"taurine efflux","id":"taurine-efflux","score":0.6411,"url":"https://openalex.org/keywords/taurine-efflux"},{"display_name":"tolrestat","id":"tolrestat","score":0.6776,"url":"https://openalex.org/keywords/tolrestat"},{"display_name":"aldo-keto reductase superfamily","id":"aldo-keto-reductase-superfamily","score":0.5859,"url":"https://openalex.org/keywords/aldo-keto-reductase-superfamily"},{"display_name":"plasma taurine","id":"plasma-taurine","score":0.6951,"url":"https://openalex.org/keywords/plasma-taurine"},{"display_name":"taurine depletion","id":"taurine-depletion","score":0.7762,"url":"https://openalex.org/keywords/taurine-depletion"}],"legacy_keywords":["Aldose Reductase","Taurine","Oxidative Stress","Diabetes","Aldo-Keto Reductase Superfamily","Hyperosmotic Stress","Inflammation","Mitochondrial Function","Neuroprotection","Cardiovascular Function"],"openalex_id":"https://openalex.org/T12533","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T12533","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12533","works_count":16547,"label":"Aldose Reductase and Taurine","provider":"openalex","revision":"a24c9efe7c3fa5eb","taxonomy_revision":"f050b5d4780b1289","title":"Aldose Reductase and Taurine","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285014349933135","address_version":"morton4x16-v1","coordinates":[1,13,1307,12533],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}