{"cited_by_count":336333,"description":"This cluster of papers explores the role of innate lymphoid cells, particularly their interaction with IL-33, in regulating type 2 immunity, tissue homeostasis, mucosal immunity, allergic inflammation, and the interplay with the adaptive immune system. It also delves into their involvement in various inflammatory diseases and their influence on regulatory T cells.","display_name":"IL-33, ST2, and ILC Pathways","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12528","wikipedia":"https://en.wikipedia.org/wiki/Innate_lymphoid_cell"},"field_id":"24","id":"T12528","keywords":[{"display_name":"IL-33","id":"il-33","score":0.3458,"url":"https://openalex.org/keywords/il-33"},{"display_name":"ILC2","id":"group-2-innate-lymphoid-cells","score":0.6567,"url":"https://openalex.org/keywords/group-2-innate-lymphoid-cells"},{"display_name":"innate lymphoid cells","id":"innate-lymphoid-cells","score":0.447,"url":"https://openalex.org/keywords/innate-lymphoid-cells"},{"display_name":"ILC3","id":"ilc3","score":0.6075,"url":"https://openalex.org/keywords/ilc3"},{"display_name":"ST2","id":"st2","score":0.2259,"url":"https://openalex.org/keywords/st2"},{"display_name":"ILC1","id":"ilc1","score":0.6928,"url":"https://openalex.org/keywords/ilc1"},{"display_name":"ST2 receptor","id":"st2-receptor","score":0.5979,"url":"https://openalex.org/keywords/st2-receptor"},{"display_name":"IL-1 family cytokines","id":"il-1-cytokine-family","score":0.3179,"url":"https://openalex.org/keywords/il-1-cytokine-family"},{"display_name":"tuft cells","id":"tuft-cells","score":0.2327,"url":"https://openalex.org/keywords/tuft-cells"},{"display_name":"lymphoid tissue inducer cells","id":"lymphoid-tissue-inducer-cells","score":0.3351,"url":"https://openalex.org/keywords/lymphoid-tissue-inducer-cells"},{"display_name":"IL-33 receptor","id":"il-33-receptor","score":0.5171,"url":"https://openalex.org/keywords/il-33-receptor"},{"display_name":"ST2L","id":"st2l","score":0.5314,"url":"https://openalex.org/keywords/st2l"},{"display_name":"ILC development","id":"ilc-development","score":0.9877,"url":"https://openalex.org/keywords/ilc-development"},{"display_name":"ILC subsets","id":"ilc-subsets","score":0.88,"url":"https://openalex.org/keywords/ilc-subsets"},{"display_name":"ILC2 activation","id":"ilc2-activation","score":0.8914,"url":"https://openalex.org/keywords/ilc2-activation"},{"display_name":"ILC plasticity","id":"ilc-plasticity","score":0.9519,"url":"https://openalex.org/keywords/ilc-plasticity"},{"display_name":"type 1 innate lymphoid cells","id":"type-1-innate-lymphoid-cells","score":0.5553,"url":"https://openalex.org/keywords/type-1-innate-lymphoid-cells"},{"display_name":"IL-33/ST2 signaling","id":"il-33-st2-signaling","score":0.474,"url":"https://openalex.org/keywords/il-33-st2-signaling"},{"display_name":"IL-33/ST2 axis","id":"il-33-st2-axis","score":0.5329,"url":"https://openalex.org/keywords/il-33-st2-axis"},{"display_name":"natural helper cells","id":"natural-helper-cells","score":0.5965,"url":"https://openalex.org/keywords/natural-helper-cells"},{"display_name":"alarmin cytokines","id":"alarmin-cytokines","score":0.4989,"url":"https://openalex.org/keywords/alarmin-cytokines"},{"display_name":"innate lymphoid cells type 2","id":"innate-lymphoid-cells-type-2","score":0.4856,"url":"https://openalex.org/keywords/innate-lymphoid-cells-type-2"},{"display_name":"IL-33 signaling","id":"il-33-signaling","score":0.4851,"url":"https://openalex.org/keywords/il-33-signaling"},{"display_name":"barrier immunity","id":"barrier-immunity","score":0.2826,"url":"https://openalex.org/keywords/barrier-immunity"},{"display_name":"tissue-resident lymphocytes","id":"tissue-resident-lymphocytes","score":0.3237,"url":"https://openalex.org/keywords/tissue-resident-lymphocytes"}],"legacy_keywords":["Innate Lymphoid Cells","IL-33","Type 2 Immunity","Tissue Homeostasis","Interleukin-1 Family","Mucosal Immunity","Allergic Inflammation","Regulatory T Cells","Adaptive Immune System","Inflammatory Diseases"],"openalex_id":"https://openalex.org/T12528","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T12528","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12528","works_count":10285,"label":"IL-33, ST2, and ILC Pathways","provider":"openalex","revision":"01538bd5c967321b","taxonomy_revision":"f050b5d4780b1289","title":"IL-33, ST2, and ILC Pathways","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38350985118752837","address_version":"morton4x16-v1","coordinates":[1,24,2403,12528],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}