{"cited_by_count":212048,"description":"This cluster of papers explores the role of fibroblast activation in cancer progression, focusing on the expression of fibroblast activation protein, immunosuppression in the tumor microenvironment, N-terminal acetylation of proteins, protease inhibitors for cancer therapy, angiogenesis, and PET imaging to target stromal cells in the tumor microenvironment.","display_name":"Peptidase Inhibition and Analysis","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12505","wikipedia":"https://en.wikipedia.org/wiki/Fibroblast_activation_protein"},"field_id":"27","id":"T12505","keywords":[{"display_name":"fibroblast activation protein","id":"fibroblast-activation-protein","score":0.343,"url":"https://openalex.org/keywords/fibroblast-activation-protein"},{"display_name":"fibroblast activation protein inhibitor","id":"fibroblast-activation-protein-inhibitor","score":0.449,"url":"https://openalex.org/keywords/fibroblast-activation-protein-inhibitor"},{"display_name":"prolyl oligopeptidase","id":"prolyl-oligopeptidase","score":0.2936,"url":"https://openalex.org/keywords/prolyl-oligopeptidase"},{"display_name":"68Ga-FAPI","id":"68ga-fapi","score":0.6078,"url":"https://openalex.org/keywords/68ga-fapi"},{"display_name":"prolyl endopeptidase","id":"prolyl-endopeptidase","score":0.2447,"url":"https://openalex.org/keywords/prolyl-endopeptidase"},{"display_name":"dipeptidase","id":"dipeptidase","score":0.2205,"url":"https://openalex.org/keywords/dipeptidase"},{"display_name":"68Ga-FAPI-04","id":"68ga-fapi-04","score":0.6167,"url":"https://openalex.org/keywords/68ga-fapi-04"},{"display_name":"aminopeptidase A","id":"aminopeptidase-a","score":0.2051,"url":"https://openalex.org/keywords/aminopeptidase-a"},{"display_name":"FAP inhibitors","id":"fap-inhibitors","score":0.6098,"url":"https://openalex.org/keywords/fap-inhibitors"},{"display_name":"DPP9","id":"dpp9","score":0.3234,"url":"https://openalex.org/keywords/dpp9"},{"display_name":"FAPI-04","id":"fapi-04","score":0.6037,"url":"https://openalex.org/keywords/fapi-04"},{"display_name":"68Ga-FAPI PET/CT","id":"68ga-fapi-pet-ct","score":0.567,"url":"https://openalex.org/keywords/68ga-fapi-pet-ct"},{"display_name":"aminopeptidase B","id":"aminopeptidase-b","score":0.3883,"url":"https://openalex.org/keywords/aminopeptidase-b"},{"display_name":"FAPI PET/CT","id":"fapi-pet-ct","score":0.5995,"url":"https://openalex.org/keywords/fapi-pet-ct"},{"display_name":"arylamidase","id":"arylamidase","score":0.2515,"url":"https://openalex.org/keywords/arylamidase"},{"display_name":"dipeptide hydrolysis","id":"dipeptide-hydrolysis","score":0.2246,"url":"https://openalex.org/keywords/dipeptide-hydrolysis"},{"display_name":"gallium-68 radiotracer","id":"gallium-68-radiotracer","score":0.2705,"url":"https://openalex.org/keywords/gallium-68-radiotracer"},{"display_name":"dipeptidyl aminopeptidase","id":"dipeptidyl-aminopeptidase","score":0.3259,"url":"https://openalex.org/keywords/dipeptidyl-aminopeptidase"},{"display_name":"aminopeptidase P","id":"aminopeptidase-p","score":0.2647,"url":"https://openalex.org/keywords/aminopeptidase-p"},{"display_name":"DPP8","id":"dipeptidyl-peptidase-8","score":0.4038,"url":"https://openalex.org/keywords/dipeptidyl-peptidase-8"},{"display_name":"68Ga-FAPI-46","id":"68ga-fapi-46","score":0.6311,"url":"https://openalex.org/keywords/68ga-fapi-46"},{"display_name":"aminopeptidase inhibitors","id":"aminopeptidase-inhibitors","score":0.2112,"url":"https://openalex.org/keywords/aminopeptidase-inhibitors"},{"display_name":"dipeptidyl peptidase III","id":"dipeptidyl-peptidase-iii","score":0.3381,"url":"https://openalex.org/keywords/dipeptidyl-peptidase-iii"},{"display_name":"FAPI-46","id":"fapi-46","score":0.4425,"url":"https://openalex.org/keywords/fapi-46"},{"display_name":"cystine aminopeptidase","id":"cystine-aminopeptidase","score":0.336,"url":"https://openalex.org/keywords/cystine-aminopeptidase"}],"legacy_keywords":["Fibroblast Activation Protein","Tumor Microenvironment","Immunosuppression","Cancer Therapy","N-terminal Acetylation","Protease Inhibitors","Angiogenesis","PET Imaging","Stromal Cells","Tumor Stroma"],"openalex_id":"https://openalex.org/T12505","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T12505","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12505","works_count":11919,"label":"Peptidase Inhibition and Analysis","provider":"openalex","revision":"f8346482b321c9c0","taxonomy_revision":"f050b5d4780b1289","title":"Peptidase Inhibition and Analysis","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351243815084394","address_version":"morton4x16-v1","coordinates":[4,27,2730,12505],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}