{"cited_by_count":341622,"description":"This cluster of papers focuses on the development and efficacy of immunotoxin therapy for cancer treatment, with a particular emphasis on ricin poisoning, ribosome-inactivating proteins, and targeted therapy using recombinant immunotoxins. It also explores the use of IL-13 receptor and mistletoe extract in cancer therapy.","display_name":"Toxin Mechanisms and Immunotoxins","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12477","wikipedia":"https://en.wikipedia.org/wiki/Immunotoxin_therapy"},"field_id":"24","id":"T12477","keywords":[{"display_name":"immunotoxins","id":"immunotoxins","score":0.6385,"url":"https://openalex.org/keywords/immunotoxins"},{"display_name":"ricin","id":"ricin","score":0.6102,"url":"https://openalex.org/keywords/ricin"},{"display_name":"ribosome-inactivating proteins","id":"ribosome-inactivating-proteins","score":0.6699,"url":"https://openalex.org/keywords/ribosome-inactivating-proteins"},{"display_name":"ricin A chain","id":"ricin-a-chain","score":0.8689,"url":"https://openalex.org/keywords/ricin-a-chain"},{"display_name":"Pseudomonas exotoxin A","id":"pseudomonas-exotoxin-a","score":0.6841,"url":"https://openalex.org/keywords/pseudomonas-exotoxin-a"},{"display_name":"Viscum album","id":"viscum-album","score":0.2252,"url":"https://openalex.org/keywords/viscum-album"},{"display_name":"ricin toxin","id":"ricin-toxin","score":0.7675,"url":"https://openalex.org/keywords/ricin-toxin"},{"display_name":"abrin","id":"abrin","score":0.6068,"url":"https://openalex.org/keywords/abrin"},{"display_name":"mistletoe extract","id":"mistletoe-extract","score":0.3502,"url":"https://openalex.org/keywords/mistletoe-extract"},{"display_name":"recombinant immunotoxin","id":"recombinant-immunotoxin","score":0.8317,"url":"https://openalex.org/keywords/recombinant-immunotoxin"},{"display_name":"Pseudomonas exotoxin","id":"pseudomonas-exotoxin","score":0.7216,"url":"https://openalex.org/keywords/pseudomonas-exotoxin"},{"display_name":"ricin B chain","id":"ricin-b-chain","score":0.8289,"url":"https://openalex.org/keywords/ricin-b-chain"},{"display_name":"trichosanthin","id":"trichosanthin","score":0.4914,"url":"https://openalex.org/keywords/trichosanthin"},{"display_name":"saporin","id":"saporin","score":0.4659,"url":"https://openalex.org/keywords/saporin"},{"display_name":"gelonin","id":"gelonin","score":0.7476,"url":"https://openalex.org/keywords/gelonin"},{"display_name":"mistletoe lectin","id":"mistletoe-lectin","score":0.6249,"url":"https://openalex.org/keywords/mistletoe-lectin"},{"display_name":"ribosome inactivation","id":"ribosome-inactivation","score":0.451,"url":"https://openalex.org/keywords/ribosome-inactivation"},{"display_name":"toxin mechanism of action","id":"toxin-mechanism-of-action","score":0.2142,"url":"https://openalex.org/keywords/toxin-mechanism-of-action"},{"display_name":"toxin internalization","id":"toxin-internalization","score":0.2799,"url":"https://openalex.org/keywords/toxin-internalization"},{"display_name":"protein toxins","id":"protein-toxins","score":0.2172,"url":"https://openalex.org/keywords/protein-toxins"},{"display_name":"pokeweed antiviral protein","id":"pokeweed-antiviral-protein","score":0.6193,"url":"https://openalex.org/keywords/pokeweed-antiviral-protein"},{"display_name":"exotoxin A","id":"exotoxin-a","score":0.2526,"url":"https://openalex.org/keywords/exotoxin-a"},{"display_name":"chimeric toxin","id":"chimeric-toxin","score":0.6021,"url":"https://openalex.org/keywords/chimeric-toxin"},{"display_name":"ricin toxicity","id":"ricin-toxicity","score":0.6954,"url":"https://openalex.org/keywords/ricin-toxicity"},{"display_name":"onconase","id":"onconase","score":0.5256,"url":"https://openalex.org/keywords/onconase"}],"legacy_keywords":["Immunotoxin","Ricin Poisoning","Ribosome-Inactivating Proteins","Cancer Therapy","Diphtheria Toxin","Targeted Therapy","Recombinant Immunotoxin","IL-13 Receptor","Ricinus communis","Mistletoe Extract"],"openalex_id":"https://openalex.org/T12477","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T12477","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12477","works_count":19411,"label":"Toxin Mechanisms and Immunotoxins","provider":"openalex","revision":"5e47da78ce514ab7","taxonomy_revision":"f050b5d4780b1289","title":"Toxin Mechanisms and Immunotoxins","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38350984984569933","address_version":"morton4x16-v1","coordinates":[1,24,2403,12477],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}