{"cited_by_count":583378,"description":"This cluster of papers focuses on the molecular regulation and clinical applications of cyclic nucleotide phosphodiesterases (PDEs), particularly in the context of cAMP signaling, schizophrenia genetics, neuronal development, therapeutic targeting, compartmentalized signaling, Alzheimer's disease treatment, cardiac function regulation, and the development of phosphodiesterase inhibitors.","display_name":"Phosphodiesterase function and regulation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12434","wikipedia":"https://en.wikipedia.org/wiki/Phosphodiesterase"},"field_id":"13","id":"T12434","keywords":[{"display_name":"phosphodiesterase inhibitors","id":"phosphodiesterase-inhibitors","score":0.2836,"url":"https://openalex.org/keywords/phosphodiesterase-inhibitors"},{"display_name":"phosphodiesterase","id":"phosphodiesterase","score":0.2751,"url":"https://openalex.org/keywords/phosphodiesterase"},{"display_name":"cyclic nucleotide phosphodiesterase","id":"cyclic-nucleotide-phosphodiesterase","score":0.6917,"url":"https://openalex.org/keywords/cyclic-nucleotide-phosphodiesterase"},{"display_name":"cyclic nucleotides","id":"cyclic-nucleotides","score":0.261,"url":"https://openalex.org/keywords/cyclic-nucleotides"},{"display_name":"phosphodiesterase-4 inhibitors","id":"phosphodiesterase-4-inhibitors","score":0.24,"url":"https://openalex.org/keywords/phosphodiesterase-4-inhibitors"},{"display_name":"phosphodiesterase 4","id":"phosphodiesterase-4","score":0.6503,"url":"https://openalex.org/keywords/phosphodiesterase-4"},{"display_name":"rolipram","id":"rolipram","score":0.4414,"url":"https://openalex.org/keywords/rolipram"},{"display_name":"cyclic AMP phosphodiesterase","id":"cyclic-amp-phosphodiesterase","score":0.6959,"url":"https://openalex.org/keywords/cyclic-amp-phosphodiesterase"},{"display_name":"phosphodiesterase inhibition","id":"phosphodiesterase-inhibition","score":0.2094,"url":"https://openalex.org/keywords/phosphodiesterase-inhibition"},{"display_name":"phosphodiesterase 5","id":"phosphodiesterase-type-5","score":0.4176,"url":"https://openalex.org/keywords/phosphodiesterase-type-5"},{"display_name":"PDE10A","id":"pde10a","score":0.584,"url":"https://openalex.org/keywords/pde10a"},{"display_name":"PDE4D","id":"pde4d","score":0.4384,"url":"https://openalex.org/keywords/pde4d"},{"display_name":"phosphodiesterase 3","id":"phosphodiesterase-3","score":0.6839,"url":"https://openalex.org/keywords/phosphodiesterase-3"},{"display_name":"cAMP phosphodiesterase","id":"camp-phosphodiesterase","score":0.4374,"url":"https://openalex.org/keywords/camp-phosphodiesterase"},{"display_name":"PDE4B","id":"pde4b","score":0.4695,"url":"https://openalex.org/keywords/pde4b"},{"display_name":"cAMP hydrolysis","id":"camp-hydrolysis","score":0.8364,"url":"https://openalex.org/keywords/camp-hydrolysis"},{"display_name":"phosphodiesterase III inhibitor","id":"phosphodiesterase-iii-inhibitors","score":0.2265,"url":"https://openalex.org/keywords/phosphodiesterase-iii-inhibitors"},{"display_name":"PDE2","id":"pde2","score":0.663,"url":"https://openalex.org/keywords/pde2"},{"display_name":"cGMP hydrolysis","id":"cgmp-hydrolysis","score":0.7113,"url":"https://openalex.org/keywords/cgmp-hydrolysis"},{"display_name":"cGMP phosphodiesterase","id":"cgmp-phosphodiesterase","score":0.39,"url":"https://openalex.org/keywords/cgmp-phosphodiesterase"},{"display_name":"cyclic GMP 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Receptors"],"openalex_id":"https://openalex.org/T12434","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T12434","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12434","works_count":24638,"label":"Phosphodiesterase function and regulation","provider":"openalex","revision":"9db084e2e05e0579","taxonomy_revision":"f050b5d4780b1289","title":"Phosphodiesterase function and regulation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38285014211240579","address_version":"morton4x16-v1","coordinates":[1,13,1312,12434],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}