{"cited_by_count":889613,"description":"This cluster of papers focuses on the diagnosis and management of adrenal insufficiency, particularly in the context of septic shock and autoimmune polyendocrine syndrome. It covers topics such as corticosteroid therapy, hydrocortisone treatment, AIRE gene mutations, cortisol response, and the impact on the hypothalamic-pituitary-adrenal axis. The research also delves into glucocorticoid replacement, autoimmune disorders, and endocrine dysfunction.","display_name":"Adrenal Hormones and Disorders","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12421","wikipedia":"https://en.wikipedia.org/wiki/Adrenal_insufficiency"},"field_id":"27","id":"T12421","keywords":[{"display_name":"adrenal insufficiency","id":"adrenal-insufficiency","score":0.5169,"url":"https://openalex.org/keywords/adrenal-insufficiency"},{"display_name":"ACTH","id":"acth","score":0.2094,"url":"https://openalex.org/keywords/acth"},{"display_name":"adrenal cortex","id":"adrenal-cortex","score":0.3969,"url":"https://openalex.org/keywords/adrenal-cortex"},{"display_name":"Addison's disease","id":"addison-s-disease","score":0.6833,"url":"https://openalex.org/keywords/addison-s-disease"},{"display_name":"ACTH stimulation test","id":"acth-stimulation-test","score":0.5099,"url":"https://openalex.org/keywords/acth-stimulation-test"},{"display_name":"cortisone","id":"cortisone","score":0.2071,"url":"https://openalex.org/keywords/cortisone"},{"display_name":"adrenal crisis","id":"adrenal-crisis","score":0.6967,"url":"https://openalex.org/keywords/adrenal-crisis"},{"display_name":"adrenal function","id":"adrenal-function","score":0.4733,"url":"https://openalex.org/keywords/adrenal-function"},{"display_name":"adrenocortical function","id":"adrenocortical-function","score":0.477,"url":"https://openalex.org/keywords/adrenocortical-function"},{"display_name":"adrenal cortex hormones","id":"adrenocortical-hormones","score":0.3716,"url":"https://openalex.org/keywords/adrenocortical-hormones"},{"display_name":"secondary adrenal insufficiency","id":"secondary-adrenal-insufficiency","score":0.6446,"url":"https://openalex.org/keywords/secondary-adrenal-insufficiency"},{"display_name":"adrenal hormones","id":"adrenal-hormones","score":0.3229,"url":"https://openalex.org/keywords/adrenal-hormones"},{"display_name":"glucocorticoid replacement therapy","id":"glucocorticoid-replacement-therapy","score":0.558,"url":"https://openalex.org/keywords/glucocorticoid-replacement-therapy"},{"display_name":"17-ketosteroids","id":"17-ketosteroids","score":0.2947,"url":"https://openalex.org/keywords/17-ketosteroids"},{"display_name":"adrenal function testing","id":"adrenal-function-testing","score":0.6559,"url":"https://openalex.org/keywords/adrenal-function-testing"},{"display_name":"pituitary-adrenal axis","id":"pituitary-adrenal-axis","score":0.2558,"url":"https://openalex.org/keywords/pituitary-adrenal-axis"},{"display_name":"adrenal suppression","id":"adrenal-suppression","score":0.4927,"url":"https://openalex.org/keywords/adrenal-suppression"},{"display_name":"adrenal disorders","id":"adrenal-diseases","score":0.3413,"url":"https://openalex.org/keywords/adrenal-diseases"},{"display_name":"adrenal steroidogenesis","id":"adrenal-steroidogenesis","score":0.3636,"url":"https://openalex.org/keywords/adrenal-steroidogenesis"},{"display_name":"mineralocorticoids","id":"mineralocorticoids","score":0.2344,"url":"https://openalex.org/keywords/mineralocorticoids"},{"display_name":"ACTH secretion","id":"acth-secretion","score":0.2101,"url":"https://openalex.org/keywords/acth-secretion"},{"display_name":"deoxycorticosterone","id":"deoxycorticosterone","score":0.213,"url":"https://openalex.org/keywords/deoxycorticosterone"},{"display_name":"17-hydroxycorticosteroids","id":"17-hydroxycorticosteroids","score":0.4499,"url":"https://openalex.org/keywords/17-hydroxycorticosteroids"},{"display_name":"adrenal hemorrhage","id":"adrenal-hemorrhage","score":0.3303,"url":"https://openalex.org/keywords/adrenal-hemorrhage"},{"display_name":"ACTH deficiency","id":"acth-deficiency","score":0.3769,"url":"https://openalex.org/keywords/acth-deficiency"}],"legacy_keywords":["Adrenal Insufficiency","Corticosteroid Therapy","Septic Shock","Autoimmune Polyendocrine Syndrome","Hydrocortisone Treatment","Glucocorticoid Replacement","AIRE Gene Mutations","Cortisol Response","Endocrine Disorders","Hypothalamic-Pituitary-Adrenal Axis Dysfunction"],"openalex_id":"https://openalex.org/T12421","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2712","url":"/topics/T12421","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12421","works_count":91809,"label":"Adrenal Hormones and Disorders","provider":"openalex","revision":"e78bb617beb9be93","taxonomy_revision":"f050b5d4780b1289","title":"Adrenal Hormones and Disorders","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351243676379434","address_version":"morton4x16-v1","coordinates":[4,27,2712,12421],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}