{"cited_by_count":255132,"description":"This cluster of papers focuses on the diagnosis, treatment, and molecular characterization of Cancer of Unknown Primary (CUP) site. It includes research on metastatic patterns, molecular profiling to identify tissue of origin, immunohistochemical markers, diagnostic algorithms, and clinical management strategies.","display_name":"Cancer Diagnosis and Treatment","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12379","wikipedia":"https://en.wikipedia.org/wiki/Cancer_of_unknown_primary_origin"},"field_id":"27","id":"T12379","keywords":[{"display_name":"cancer of unknown primary","id":"cancer-of-unknown-primary","score":0.483,"url":"https://openalex.org/keywords/cancer-of-unknown-primary"},{"display_name":"occult primary tumor","id":"occult-primary-tumor","score":0.3399,"url":"https://openalex.org/keywords/occult-primary-tumor"},{"display_name":"primary tumor detection","id":"primary-tumor-identification","score":0.3733,"url":"https://openalex.org/keywords/primary-tumor-identification"},{"display_name":"adenocarcinoma of unknown primary","id":"adenocarcinoma-of-unknown-primary","score":0.4117,"url":"https://openalex.org/keywords/adenocarcinoma-of-unknown-primary"},{"display_name":"CUP syndrome","id":"cup-syndrome","score":0.526,"url":"https://openalex.org/keywords/cup-syndrome"},{"display_name":"unknown primary site","id":"unknown-primary-site","score":0.3079,"url":"https://openalex.org/keywords/unknown-primary-site"},{"display_name":"primary site identification","id":"primary-site-identification","score":0.6719,"url":"https://openalex.org/keywords/primary-site-identification"},{"display_name":"primary tumor site identification","id":"primary-tumor-site-identification","score":0.456,"url":"https://openalex.org/keywords/primary-tumor-site-identification"},{"display_name":"malignant tumor diagnosis","id":"malignant-tumor-diagnosis","score":0.2642,"url":"https://openalex.org/keywords/malignant-tumor-diagnosis"},{"display_name":"squamous cell carcinoma of unknown primary","id":"squamous-cell-carcinoma-of-unknown-primary","score":0.3385,"url":"https://openalex.org/keywords/squamous-cell-carcinoma-of-unknown-primary"},{"display_name":"site-specific therapy","id":"site-specific-therapy","score":0.543,"url":"https://openalex.org/keywords/site-specific-therapy"},{"display_name":"tissue of origin identification","id":"tissue-of-origin-identification","score":0.4331,"url":"https://openalex.org/keywords/tissue-of-origin-identification"},{"display_name":"tissue of origin prediction","id":"tissue-of-origin-prediction","score":0.3079,"url":"https://openalex.org/keywords/tissue-of-origin-prediction"},{"display_name":"tumor node metastasis","id":"tumor-node-metastasis","score":0.2732,"url":"https://openalex.org/keywords/tumor-node-metastasis"},{"display_name":"tumor origin identification","id":"tumor-origin-identification","score":0.2811,"url":"https://openalex.org/keywords/tumor-origin-identification"},{"display_name":"occult primary malignancy","id":"occult-primary-malignancy","score":0.238,"url":"https://openalex.org/keywords/occult-primary-malignancy"},{"display_name":"cancer immunodiagnosis","id":"cancer-immunodiagnosis","score":0.3369,"url":"https://openalex.org/keywords/cancer-immunodiagnosis"},{"display_name":"surgical cytology","id":"surgical-cytology","score":0.2721,"url":"https://openalex.org/keywords/surgical-cytology"},{"display_name":"molecularly guided therapy","id":"molecularly-guided-therapy","score":0.2114,"url":"https://openalex.org/keywords/molecularly-guided-therapy"},{"display_name":"primary tumor search","id":"primary-tumor-search","score":0.2406,"url":"https://openalex.org/keywords/primary-tumor-search"},{"display_name":"cell examination","id":"cell-examination","score":0.201,"url":"https://openalex.org/keywords/cell-examination"}],"legacy_keywords":["Cancer of Unknown Primary","Metastasis","Tissue of Origin","Molecular Profiling","Immunohistochemistry","Diagnostic Algorithm","Soft Tissue Metastases","Gene Expression Profiling","Unknown Primary Tumours","Clinical Management"],"openalex_id":"https://openalex.org/T12379","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T12379","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12379","works_count":20927,"label":"Cancer Diagnosis and Treatment","provider":"openalex","revision":"87c537883c4fe6f3","taxonomy_revision":"f050b5d4780b1289","title":"Cancer Diagnosis and Treatment","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351241667600874","address_version":"morton4x16-v1","coordinates":[4,27,2730,12379],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}