{"cited_by_count":372716,"description":"This cluster of papers explores the role of quinones in toxicology and pharmacology, focusing on their cytotoxic effects, NAD(P)H:Quinone Oxidoreductase activity, apoptosis induction, and potential as anticancer and antimicrobial agents. The papers cover a wide range of topics including cellular pharmacology studies, mechanisms of cytotoxic action, pharmacological properties, and the synthesis and evaluation of quinone derivatives.","display_name":"Bioactive Compounds and Antitumor Agents","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12356","wikipedia":"https://en.wikipedia.org/wiki/Quinone_toxicity"},"field_id":"30","id":"T12356","keywords":[{"display_name":"naphthoquinones","id":"naphthoquinones","score":0.2375,"url":"https://openalex.org/keywords/naphthoquinones"},{"display_name":"1,4-naphthoquinone","id":"1-4-naphthoquinone","score":0.2047,"url":"https://openalex.org/keywords/1-4-naphthoquinone"},{"display_name":"\u03b2-lapachone","id":"beta-lapachone","score":0.365,"url":"https://openalex.org/keywords/beta-lapachone"},{"display_name":"DT-diaphorase","id":"dt-diaphorase","score":0.3592,"url":"https://openalex.org/keywords/dt-diaphorase"},{"display_name":"lapachol","id":"lapachol","score":0.2927,"url":"https://openalex.org/keywords/lapachol"},{"display_name":"NAD(P)H:quinone oxidoreductase 1","id":"nad-p-h-quinone-oxidoreductase-1","score":0.2488,"url":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase-1"},{"display_name":"NAD(P)H:quinone oxidoreductase","id":"nad-p-h-quinone-oxidoreductase","score":0.319,"url":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase"},{"display_name":"1,4-naphthoquinone derivatives","id":"1-4-naphthoquinone-derivatives","score":0.4411,"url":"https://openalex.org/keywords/1-4-naphthoquinone-derivatives"},{"display_name":"naphthoquinone synthesis","id":"naphthoquinone-synthesis","score":0.3058,"url":"https://openalex.org/keywords/naphthoquinone-synthesis"},{"display_name":"quinone chemistry","id":"quinone-chemistry","score":0.2015,"url":"https://openalex.org/keywords/quinone-chemistry"},{"display_name":"shikonin derivatives","id":"shikonin-derivatives","score":0.3447,"url":"https://openalex.org/keywords/shikonin-derivatives"},{"display_name":"bioreductive activation","id":"bioreductive-activation","score":0.4515,"url":"https://openalex.org/keywords/bioreductive-activation"},{"display_name":"quinone toxicity","id":"quinone-toxicity","score":0.4389,"url":"https://openalex.org/keywords/quinone-toxicity"},{"display_name":"NQO2","id":"nqo2","score":0.2804,"url":"https://openalex.org/keywords/nqo2"},{"display_name":"bioreductive drugs","id":"bioreductive-drugs","score":0.2693,"url":"https://openalex.org/keywords/bioreductive-drugs"},{"display_name":"bioreductive alkylating agents","id":"bioreductive-alkylating-agents","score":0.5831,"url":"https://openalex.org/keywords/bioreductive-alkylating-agents"},{"display_name":"quinone metabolism","id":"quinone-metabolism","score":0.3862,"url":"https://openalex.org/keywords/quinone-metabolism"},{"display_name":"\u03b1-lapachone","id":"alpha-lapachone","score":0.5034,"url":"https://openalex.org/keywords/alpha-lapachone"},{"display_name":"indolequinones","id":"indolequinones","score":0.353,"url":"https://openalex.org/keywords/indolequinones"},{"display_name":"EO9","id":"eo9","score":0.579,"url":"https://openalex.org/keywords/eo9"},{"display_name":"acetylshikonin","id":"acetylshikonin","score":0.2384,"url":"https://openalex.org/keywords/acetylshikonin"},{"display_name":"quinone detoxification","id":"quinone-detoxification","score":0.4296,"url":"https://openalex.org/keywords/quinone-detoxification"},{"display_name":"quinone reductase 2","id":"quinone-reductase-2","score":0.2471,"url":"https://openalex.org/keywords/quinone-reductase-2"},{"display_name":"diaziquone","id":"diaziquone","score":0.2804,"url":"https://openalex.org/keywords/diaziquone"},{"display_name":"NQO1 inhibitors","id":"nqo1-inhibitors","score":0.4647,"url":"https://openalex.org/keywords/nqo1-inhibitors"}],"legacy_keywords":["Quinones","Toxicology","Pharmacology","Cytotoxicity","NAD(P)H:Quinone Oxidoreductase","Apoptosis","Anticancer Agents","Reactive Oxygen Species","Antimicrobial Activity","Cell Signaling"],"openalex_id":"https://openalex.org/T12356","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"3005","url":"/topics/T12356","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12356","works_count":24723,"label":"Bioactive Compounds and Antitumor Agents","provider":"openalex","revision":"a47b90e63f87e3ed","taxonomy_revision":"f050b5d4780b1289","title":"Bioactive Compounds and Antitumor Agents","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351258847178277","address_version":"morton4x16-v1","coordinates":[1,30,3005,12356],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}