{"cited_by_count":160337,"description":"This cluster of papers focuses on the phenomenon of Heparin-Induced Thrombocytopenia (HIT) and its associated thrombotic complications, particularly in the context of vaccination. The papers cover various aspects including pathogenesis, diagnosis, management, immune response, and the role of anticoagulation therapy in HIT. Additionally, they explore the clinical features and outcomes related to HIT and thrombosis.","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12352","wikipedia":"https://en.wikipedia.org/wiki/Heparin-induced_thrombocytopenia"},"field_id":"27","id":"T12352","keywords":[{"display_name":"heparin-induced thrombocytopenia","id":"heparin-induced-thrombocytopenia","score":0.7134,"url":"https://openalex.org/keywords/heparin-induced-thrombocytopenia"},{"display_name":"platelet factor 4","id":"platelet-factor-4","score":0.2412,"url":"https://openalex.org/keywords/platelet-factor-4"},{"display_name":"argatroban","id":"argatroban","score":0.3771,"url":"https://openalex.org/keywords/argatroban"},{"display_name":"vaccine-induced immune thrombotic thrombocytopenia","id":"vaccine-induced-thrombotic-thrombocytopenia","score":0.7028,"url":"https://openalex.org/keywords/vaccine-induced-thrombotic-thrombocytopenia"},{"display_name":"anticoagulant adverse effects","id":"anticoagulant-adverse-effects","score":0.236,"url":"https://openalex.org/keywords/anticoagulant-adverse-effects"},{"display_name":"serotonin release assay","id":"serotonin-release-assay","score":0.9532,"url":"https://openalex.org/keywords/serotonin-release-assay"},{"display_name":"heparin-induced thrombocytopenia type II","id":"heparin-induced-thrombocytopenia-type-ii","score":0.8773,"url":"https://openalex.org/keywords/heparin-induced-thrombocytopenia-type-ii"},{"display_name":"4Ts score","id":"4ts-score","score":0.966,"url":"https://openalex.org/keywords/4ts-score"},{"display_name":"platelet factor 4 antibodies","id":"anti-platelet-factor-4-antibodies","score":0.8458,"url":"https://openalex.org/keywords/anti-platelet-factor-4-antibodies"},{"display_name":"lepirudin","id":"lepirudin","score":0.5602,"url":"https://openalex.org/keywords/lepirudin"},{"display_name":"anti-PF4 antibodies","id":"anti-pf4-antibodies","score":0.8848,"url":"https://openalex.org/keywords/anti-pf4-antibodies"},{"display_name":"danaparoid","id":"danaparoid","score":0.5556,"url":"https://openalex.org/keywords/danaparoid"},{"display_name":"anti-PF4/heparin antibodies","id":"anti-pf4-heparin-antibodies","score":0.9605,"url":"https://openalex.org/keywords/anti-pf4-heparin-antibodies"},{"display_name":"anticoagulation alternatives","id":"alternative-anticoagulants","score":0.3155,"url":"https://openalex.org/keywords/alternative-anticoagulants"},{"display_name":"alternative anticoagulation","id":"alternative-anticoagulation","score":0.8712,"url":"https://openalex.org/keywords/alternative-anticoagulation"},{"display_name":"heparin-platelet factor 4 antibodies","id":"heparin-platelet-factor-4-antibodies","score":0.9456,"url":"https://openalex.org/keywords/heparin-platelet-factor-4-antibodies"},{"display_name":"HIT antibodies","id":"hit-antibodies","score":0.9481,"url":"https://openalex.org/keywords/hit-antibodies"},{"display_name":"platelet count monitoring","id":"platelet-count-monitoring","score":0.248,"url":"https://openalex.org/keywords/platelet-count-monitoring"},{"display_name":"heparin discontinuation","id":"heparin-discontinuation","score":0.6467,"url":"https://openalex.org/keywords/heparin-discontinuation"},{"display_name":"PF4/heparin antibodies","id":"pf4-heparin-antibodies","score":0.953,"url":"https://openalex.org/keywords/pf4-heparin-antibodies"},{"display_name":"thrombosis with thrombocytopenia syndrome","id":"thrombosis-with-thrombocytopenia-syndrome","score":0.3987,"url":"https://openalex.org/keywords/thrombosis-with-thrombocytopenia-syndrome"},{"display_name":"heparin antibodies","id":"heparin-antibodies","score":0.8653,"url":"https://openalex.org/keywords/heparin-antibodies"},{"display_name":"platelet-activating antibodies","id":"platelet-activating-antibodies","score":0.9677,"url":"https://openalex.org/keywords/platelet-activating-antibodies"},{"display_name":"PF4 antibodies","id":"pf4-antibodies","score":0.8723,"url":"https://openalex.org/keywords/pf4-antibodies"},{"display_name":"heparin-induced skin necrosis","id":"heparin-induced-skin-necrosis","score":0.7609,"url":"https://openalex.org/keywords/heparin-induced-skin-necrosis"}],"legacy_keywords":["Heparin-Induced Thrombocytopenia","Thrombosis","Vaccination","PF4 Antibodies","Immune Response","Anticoagulation Therapy","Platelet Activation","Diagnosis","Management","Clinical Features"],"openalex_id":"https://openalex.org/T12352","source_created_date":"2024-01-23T15:27:14","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2746","url":"/topics/T12352","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12352","works_count":12065,"label":"Heparin-Induced Thrombocytopenia and Thrombosis","provider":"openalex","revision":"d86c657a24de94dc","taxonomy_revision":"f050b5d4780b1289","title":"Heparin-Induced Thrombocytopenia and Thrombosis","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"38351241667305826","address_version":"morton4x16-v1","coordinates":[4,27,2746,12352],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}