{"cited_by_count":429040,"description":"This cluster of papers focuses on the role of mechanosensitive ion channels, particularly Piezo1 and Piezo2, in various physiological processes such as mechanotransduction, erythrocyte function, sensory neuron response, and erythropoiesis. It also explores the implications of these channels in diseases related to erythrocytes, sensory perception, and cellular mechanosensation.","display_name":"Erythrocyte Function and Pathophysiology","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12286","wikipedia":"https://en.wikipedia.org/wiki/Mechanosensitive_ion_channel"},"field_id":"27","id":"T12286","keywords":[{"display_name":"erythrocyte membrane","id":"erythrocyte-membrane","score":0.2757,"url":"https://openalex.org/keywords/erythrocyte-membrane"},{"display_name":"hereditary spherocytosis","id":"hereditary-spherocytosis","score":0.3595,"url":"https://openalex.org/keywords/hereditary-spherocytosis"},{"display_name":"spectrin","id":"spectrin","score":0.2936,"url":"https://openalex.org/keywords/spectrin"},{"display_name":"erythrocyte metabolism","id":"erythrocyte-metabolism","score":0.3119,"url":"https://openalex.org/keywords/erythrocyte-metabolism"},{"display_name":"band 3","id":"band-3","score":0.2973,"url":"https://openalex.org/keywords/band-3"},{"display_name":"erythrocyte ghosts","id":"erythrocyte-ghosts","score":0.2164,"url":"https://openalex.org/keywords/erythrocyte-ghosts"},{"display_name":"osmotic fragility","id":"osmotic-fragility","score":0.3,"url":"https://openalex.org/keywords/osmotic-fragility"},{"display_name":"erythrocyte membrane proteins","id":"erythrocyte-membrane-proteins","score":0.3577,"url":"https://openalex.org/keywords/erythrocyte-membrane-proteins"},{"display_name":"hereditary elliptocytosis","id":"hereditary-elliptocytosis","score":0.5143,"url":"https://openalex.org/keywords/hereditary-elliptocytosis"},{"display_name":"eryptosis","id":"eryptosis","score":0.5233,"url":"https://openalex.org/keywords/eryptosis"},{"display_name":"erythrocyte aging","id":"erythrocyte-aging","score":0.4901,"url":"https://openalex.org/keywords/erythrocyte-aging"},{"display_name":"red blood cell membrane disorders","id":"red-cell-membrane-disorders","score":0.3788,"url":"https://openalex.org/keywords/red-cell-membrane-disorders"},{"display_name":"ankyrin","id":"ankyrin","score":0.3706,"url":"https://openalex.org/keywords/ankyrin"},{"display_name":"erythrocyte osmotic fragility","id":"erythrocyte-osmotic-fragility","score":0.2704,"url":"https://openalex.org/keywords/erythrocyte-osmotic-fragility"},{"display_name":"erythrocyte lifespan","id":"erythrocyte-lifespan","score":0.3287,"url":"https://openalex.org/keywords/erythrocyte-lifespan"},{"display_name":"band 3 protein","id":"band-3-protein","score":0.3572,"url":"https://openalex.org/keywords/band-3-protein"},{"display_name":"erythrocyte cytoskeleton","id":"erythrocyte-cytoskeleton","score":0.4617,"url":"https://openalex.org/keywords/erythrocyte-cytoskeleton"},{"display_name":"erythrocyte membrane permeability","id":"erythrocyte-membrane-permeability","score":0.3494,"url":"https://openalex.org/keywords/erythrocyte-membrane-permeability"},{"display_name":"membrane skeleton","id":"membrane-skeleton","score":0.2534,"url":"https://openalex.org/keywords/membrane-skeleton"},{"display_name":"erythrocyte membrane skeleton","id":"erythrocyte-membrane-skeleton","score":0.6418,"url":"https://openalex.org/keywords/erythrocyte-membrane-skeleton"},{"display_name":"spherocytes","id":"spherocytes","score":0.3255,"url":"https://openalex.org/keywords/spherocytes"},{"display_name":"protein 4.1","id":"protein-4-1","score":0.4614,"url":"https://openalex.org/keywords/protein-4-1"},{"display_name":"echinocytes","id":"echinocytes","score":0.2343,"url":"https://openalex.org/keywords/echinocytes"},{"display_name":"erythrocyte shape","id":"erythrocyte-shape","score":0.3818,"url":"https://openalex.org/keywords/erythrocyte-shape"},{"display_name":"osmotic resistance","id":"osmotic-resistance","score":0.2701,"url":"https://openalex.org/keywords/osmotic-resistance"}],"legacy_keywords":["Piezo1","Piezo2","mechanotransduction","erythrocyte","mechanosensation","ion channels","membrane","sensory neurons","erythropoiesis","apoptosis"],"openalex_id":"https://openalex.org/T12286","source_created_date":"2024-01-23T15:27:13","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2737","url":"/topics/T12286","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12286","works_count":27075,"label":"Erythrocyte Function and Pathophysiology","provider":"openalex","revision":"7bb325c45b7fbed2","taxonomy_revision":"f050b5d4780b1289","title":"Erythrocyte Function and Pathophysiology","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249561706965414","address_version":"morton4x16-v1","coordinates":[4,27,2737,12286],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}