{"cited_by_count":353417,"description":"This cluster of papers explores the multifaceted role of osteopontin in biomineralization, inflammation, immune regulation, cancer progression, and cell signaling. It delves into its influence on various conditions such as dentinogenesis imperfecta, tumor metastasis, and autoimmune demyelinating disease. The papers also discuss the involvement of matricellular proteins in modulating cell function and tissue response to injury.","display_name":"Bone and Dental Protein Studies","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12110","wikipedia":"https://en.wikipedia.org/wiki/Osteopontin"},"field_id":"27","id":"T12110","keywords":[{"display_name":"bone sialoprotein","id":"bone-sialoprotein","score":0.2031,"url":"https://openalex.org/keywords/bone-sialoprotein"},{"display_name":"amelogenin","id":"amelogenin","score":0.2152,"url":"https://openalex.org/keywords/amelogenin"},{"display_name":"enamel matrix proteins","id":"enamel-matrix-proteins","score":0.2729,"url":"https://openalex.org/keywords/enamel-matrix-proteins"},{"display_name":"enamel matrix","id":"enamel-matrix","score":0.3375,"url":"https://openalex.org/keywords/enamel-matrix"},{"display_name":"enamel mineralization","id":"enamel-mineralization","score":0.2003,"url":"https://openalex.org/keywords/enamel-mineralization"},{"display_name":"dentin mineralization","id":"dentin-mineralization","score":0.2742,"url":"https://openalex.org/keywords/dentin-mineralization"},{"display_name":"dentin sialophosphoprotein","id":"dentin-sialophosphoprotein","score":0.23,"url":"https://openalex.org/keywords/dentin-sialophosphoprotein"},{"display_name":"bone matrix proteins","id":"bone-matrix-proteins","score":0.3066,"url":"https://openalex.org/keywords/bone-matrix-proteins"},{"display_name":"non-collagenous proteins","id":"non-collagenous-proteins","score":0.2019,"url":"https://openalex.org/keywords/non-collagenous-proteins"},{"display_name":"dentin matrix","id":"dentin-matrix","score":0.2853,"url":"https://openalex.org/keywords/dentin-matrix"},{"display_name":"enamel proteins","id":"enamel-proteins","score":0.4486,"url":"https://openalex.org/keywords/enamel-proteins"},{"display_name":"dentin matrix proteins","id":"dentin-matrix-proteins","score":0.2999,"url":"https://openalex.org/keywords/dentin-matrix-proteins"},{"display_name":"predentin","id":"predentin","score":0.2723,"url":"https://openalex.org/keywords/predentin"},{"display_name":"dentin sialoprotein","id":"dentin-sialoprotein","score":0.3399,"url":"https://openalex.org/keywords/dentin-sialoprotein"},{"display_name":"enamel maturation","id":"enamel-maturation","score":0.2146,"url":"https://openalex.org/keywords/enamel-maturation"},{"display_name":"dentin phosphoprotein","id":"dentin-phosphoprotein","score":0.7013,"url":"https://openalex.org/keywords/dentin-phosphoprotein"},{"display_name":"ameloblastin","id":"ameloblastin","score":0.242,"url":"https://openalex.org/keywords/ameloblastin"},{"display_name":"enamelin","id":"enamelin","score":0.3115,"url":"https://openalex.org/keywords/enamelin"},{"display_name":"secreted protein acidic and rich in cysteine","id":"secreted-protein-acidic-and-rich-in-cysteine","score":0.299,"url":"https://openalex.org/keywords/secreted-protein-acidic-and-rich-in-cysteine"},{"display_name":"enamel biomineralization","id":"enamel-biomineralization","score":0.4467,"url":"https://openalex.org/keywords/enamel-biomineralization"},{"display_name":"phosphophoryn","id":"phosphophoryn","score":0.6883,"url":"https://openalex.org/keywords/phosphophoryn"},{"display_name":"dentinogenesis imperfecta type II","id":"dentinogenesis-imperfecta-type-ii","score":0.4377,"url":"https://openalex.org/keywords/dentinogenesis-imperfecta-type-ii"},{"display_name":"SIBLING proteins","id":"sibling-proteins","score":0.5832,"url":"https://openalex.org/keywords/sibling-proteins"},{"display_name":"hereditary dentin disorders","id":"hereditary-dentin-disorders","score":0.3293,"url":"https://openalex.org/keywords/hereditary-dentin-disorders"},{"display_name":"dentin dysplasia","id":"dentin-dysplasia","score":0.2238,"url":"https://openalex.org/keywords/dentin-dysplasia"}],"legacy_keywords":["Osteopontin","Biomineralization","Inflammation","Matricellular Proteins","Cell Signaling","Cancer Progression","Immune Regulation","Tumor Metastasis","Dentinogenesis Imperfecta","Extracellular Modulators"],"openalex_id":"https://openalex.org/T12110","source_created_date":"2024-01-23T15:27:13","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2745","url":"/topics/T12110","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12110","works_count":12224,"label":"Bone and Dental Protein Studies","provider":"openalex","revision":"121f157acfe7515e","taxonomy_revision":"f050b5d4780b1289","title":"Bone and Dental Protein Studies","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249559550585254","address_version":"morton4x16-v1","coordinates":[4,27,2745,12110],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}