{"cited_by_count":456403,"description":"This cluster of papers explores the role of the Hippo signaling pathway, particularly the involvement of YAP/TAZ, in mechanotransduction, cell proliferation, tissue growth control, organ size control, and its implications in cancer and stem cell regulation.","display_name":"Hippo pathway signaling and YAP/TAZ","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12065","wikipedia":"https://en.wikipedia.org/wiki/Hippo_signaling_pathway"},"field_id":"13","id":"T12065","keywords":[{"display_name":"Hippo signaling pathway","id":"hippo-signaling-pathway","score":0.5254,"url":"https://openalex.org/keywords/hippo-signaling-pathway"},{"display_name":"YAP","id":"yap","score":0.4579,"url":"https://openalex.org/keywords/yap"},{"display_name":"TAZ","id":"taz","score":0.6031,"url":"https://openalex.org/keywords/taz"},{"display_name":"organ size control","id":"organ-size-control","score":0.4836,"url":"https://openalex.org/keywords/organ-size-control"},{"display_name":"YAP/TAZ","id":"yap-taz","score":0.591,"url":"https://openalex.org/keywords/yap-taz"},{"display_name":"TEAD transcription factors","id":"tead-transcription-factors","score":0.7845,"url":"https://openalex.org/keywords/tead-transcription-factors"},{"display_name":"LATS1","id":"lats1","score":0.5335,"url":"https://openalex.org/keywords/lats1"},{"display_name":"YAP phosphorylation","id":"yap-phosphorylation","score":0.6585,"url":"https://openalex.org/keywords/yap-phosphorylation"},{"display_name":"Yorkie","id":"yorkie","score":0.7953,"url":"https://openalex.org/keywords/yorkie"},{"display_name":"tissue growth regulation","id":"tissue-growth-regulation","score":0.4041,"url":"https://openalex.org/keywords/tissue-growth-regulation"},{"display_name":"TEAD","id":"tead","score":0.6703,"url":"https://openalex.org/keywords/tead"},{"display_name":"LATS2","id":"lats2","score":0.378,"url":"https://openalex.org/keywords/lats2"},{"display_name":"MST1","id":"mst1","score":0.2201,"url":"https://openalex.org/keywords/mst1"},{"display_name":"LATS1/2","id":"lats1-2","score":0.7481,"url":"https://openalex.org/keywords/lats1-2"},{"display_name":"TEAD4","id":"tead4","score":0.3954,"url":"https://openalex.org/keywords/tead4"},{"display_name":"YAP/TAZ signaling","id":"yap-taz-signaling","score":0.2982,"url":"https://openalex.org/keywords/yap-taz-signaling"},{"display_name":"YAP nuclear translocation","id":"yap-nuclear-translocation","score":0.3538,"url":"https://openalex.org/keywords/yap-nuclear-translocation"},{"display_name":"TEAD1","id":"tead1","score":0.3486,"url":"https://openalex.org/keywords/tead1"},{"display_name":"MST1/2","id":"mst1-2","score":0.6971,"url":"https://openalex.org/keywords/mst1-2"},{"display_name":"LATS kinase","id":"lats-kinase","score":0.8424,"url":"https://openalex.org/keywords/lats-kinase"},{"display_name":"YAP signaling","id":"yap-signaling","score":0.2357,"url":"https://openalex.org/keywords/yap-signaling"},{"display_name":"MST2","id":"mst2","score":0.46,"url":"https://openalex.org/keywords/mst2"},{"display_name":"TEAD inhibitors","id":"tead-inhibitors","score":0.6342,"url":"https://openalex.org/keywords/tead-inhibitors"},{"display_name":"Hippo/YAP signaling","id":"hippo-yap-signaling","score":0.3229,"url":"https://openalex.org/keywords/hippo-yap-signaling"},{"display_name":"angiomotin","id":"angiomotin","score":0.3135,"url":"https://openalex.org/keywords/angiomotin"}],"legacy_keywords":["Hippo Pathway","YAP/TAZ","mechanotransduction","cell proliferation","tissue growth control","organ size control","cancer","regulation","mechanobiology","stem cells"],"openalex_id":"https://openalex.org/T12065","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T12065","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12065","works_count":14356,"label":"Hippo pathway signaling and YAP/TAZ","provider":"openalex","revision":"877af8eb391af66d","taxonomy_revision":"f050b5d4780b1289","title":"Hippo pathway signaling and YAP/TAZ","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36183329950949967","address_version":"morton4x16-v1","coordinates":[1,13,1307,12065],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}