{"cited_by_count":296810,"description":"This cluster of papers focuses on Tuberous Sclerosis Complex (TSC) and related disorders, including Lymphangioleiomyomatosis and Angiomyolipoma. It covers various aspects such as genetic mutations, neurological manifestations, use of mTOR inhibitors, diagnostic criteria, and the role of hamartin and tuberin proteins. Additionally, it explores the association with epilepsy and cognitive impairment.","display_name":"Tuberous Sclerosis Complex Research","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12049","wikipedia":"https://en.wikipedia.org/wiki/Tuberous_sclerosis"},"field_id":"27","id":"T12049","keywords":[{"display_name":"tuberous sclerosis complex","id":"tuberous-sclerosis-complex","score":0.6887,"url":"https://openalex.org/keywords/tuberous-sclerosis-complex"},{"display_name":"renal angiomyolipoma","id":"renal-angiomyolipoma","score":0.6696,"url":"https://openalex.org/keywords/renal-angiomyolipoma"},{"display_name":"lymphangioleiomyomatosis","id":"lymphangioleiomyomatosis","score":0.724,"url":"https://openalex.org/keywords/lymphangioleiomyomatosis"},{"display_name":"angiomyolipoma","id":"angiomyolipoma","score":0.4562,"url":"https://openalex.org/keywords/angiomyolipoma"},{"display_name":"TSC2","id":"tsc2","score":0.4072,"url":"https://openalex.org/keywords/tsc2"},{"display_name":"TSC1","id":"tsc1","score":0.4883,"url":"https://openalex.org/keywords/tsc1"},{"display_name":"Birt-Hogg-Dub\u00e9 syndrome","id":"birt-hogg-dube-syndrome","score":0.5219,"url":"https://openalex.org/keywords/birt-hogg-dube-syndrome"},{"display_name":"pulmonary cysts","id":"pulmonary-cysts","score":0.2309,"url":"https://openalex.org/keywords/pulmonary-cysts"},{"display_name":"subependymal giant cell astrocytoma","id":"subependymal-giant-cell-astrocytoma","score":0.778,"url":"https://openalex.org/keywords/subependymal-giant-cell-astrocytoma"},{"display_name":"PEComa","id":"perivascular-epithelioid-cell-tumor","score":0.4079,"url":"https://openalex.org/keywords/perivascular-epithelioid-cell-tumor"},{"display_name":"TSC2 gene","id":"tsc2-gene","score":0.888,"url":"https://openalex.org/keywords/tsc2-gene"},{"display_name":"cortical tubers","id":"cortical-tubers","score":0.8757,"url":"https://openalex.org/keywords/cortical-tubers"},{"display_name":"pulmonary lymphangioleiomyomatosis","id":"pulmonary-lymphangioleiomyomatosis","score":0.8617,"url":"https://openalex.org/keywords/pulmonary-lymphangioleiomyomatosis"},{"display_name":"TSC1 gene","id":"tsc1-gene","score":0.9367,"url":"https://openalex.org/keywords/tsc1-gene"},{"display_name":"tuberin","id":"tuberin","score":0.6387,"url":"https://openalex.org/keywords/tuberin"},{"display_name":"hepatic angiomyolipoma","id":"hepatic-angiomyolipoma","score":0.8201,"url":"https://openalex.org/keywords/hepatic-angiomyolipoma"},{"display_name":"cardiac rhabdomyoma","id":"cardiac-rhabdomyoma","score":0.4429,"url":"https://openalex.org/keywords/cardiac-rhabdomyoma"},{"display_name":"subependymal nodules","id":"subependymal-nodules","score":0.8697,"url":"https://openalex.org/keywords/subependymal-nodules"},{"display_name":"hamartin","id":"hamartin","score":0.7821,"url":"https://openalex.org/keywords/hamartin"},{"display_name":"facial angiofibroma","id":"facial-angiofibroma","score":0.8086,"url":"https://openalex.org/keywords/facial-angiofibroma"},{"display_name":"TSC2 mutation","id":"tsc2-mutation","score":0.6982,"url":"https://openalex.org/keywords/tsc2-mutation"},{"display_name":"fibrofolliculoma","id":"fibrofolliculoma","score":0.6851,"url":"https://openalex.org/keywords/fibrofolliculoma"},{"display_name":"cystic lung disease","id":"cystic-lung-disease","score":0.2434,"url":"https://openalex.org/keywords/cystic-lung-disease"},{"display_name":"angiofibroma","id":"angiofibroma","score":0.32,"url":"https://openalex.org/keywords/angiofibroma"},{"display_name":"epithelioid angiomyolipoma","id":"epithelioid-angiomyolipoma","score":0.7403,"url":"https://openalex.org/keywords/epithelioid-angiomyolipoma"}],"legacy_keywords":["Tuberous Sclerosis Complex","Lymphangioleiomyomatosis","Angiomyolipoma","mTOR Inhibitors","Neurological Manifestations","Genetic Mutations","Epilepsy","Diagnostic Criteria","Hamartin and Tuberin Proteins","Cognitive Impairment"],"openalex_id":"https://openalex.org/T12049","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2737","url":"/topics/T12049","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12049","works_count":22608,"label":"Tuberous Sclerosis Complex Research","provider":"openalex","revision":"b7367185ec1a96ba","taxonomy_revision":"f050b5d4780b1289","title":"Tuberous Sclerosis Complex Research","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249559416840494","address_version":"morton4x16-v1","coordinates":[4,27,2737,12049],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}