{"cited_by_count":407703,"description":"This cluster of papers focuses on the structure, function, and pathology of S100 proteins, a multigenic family of calcium-modulated proteins with roles in inflammation, neurodegeneration, cancer biomarkers, traumatic brain injury, innate immunity, glial fibrillary acidic protein, metastasis, and phagocytes.","display_name":"S100 Proteins and Annexins","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T12030","wikipedia":"https://en.wikipedia.org/wiki/S100_protein"},"field_id":"13","id":"T12030","keywords":[{"display_name":"calcium-binding proteins","id":"calcium-binding-proteins","score":0.2049,"url":"https://openalex.org/keywords/calcium-binding-proteins"},{"display_name":"annexin A1","id":"annexin-a1","score":0.28,"url":"https://openalex.org/keywords/annexin-a1"},{"display_name":"S100A9","id":"s100a9","score":0.2437,"url":"https://openalex.org/keywords/s100a9"},{"display_name":"S100A4","id":"s100a4","score":0.2385,"url":"https://openalex.org/keywords/s100a4"},{"display_name":"annexin A2","id":"annexin-a2","score":0.2342,"url":"https://openalex.org/keywords/annexin-a2"},{"display_name":"S100A8","id":"s100a8","score":0.2426,"url":"https://openalex.org/keywords/s100a8"},{"display_name":"annexins","id":"annexins","score":0.423,"url":"https://openalex.org/keywords/annexins"},{"display_name":"EF-hand proteins","id":"ef-hand-proteins","score":0.2656,"url":"https://openalex.org/keywords/ef-hand-proteins"},{"display_name":"S100A8/A9","id":"s100a8-a9","score":0.2292,"url":"https://openalex.org/keywords/s100a8-a9"},{"display_name":"S100A6","id":"s100a6","score":0.3926,"url":"https://openalex.org/keywords/s100a6"},{"display_name":"S100B protein","id":"s100b-protein","score":0.2984,"url":"https://openalex.org/keywords/s100b-protein"},{"display_name":"S100A1","id":"s100a1","score":0.4385,"url":"https://openalex.org/keywords/s100a1"},{"display_name":"annexin A6","id":"annexin-a6","score":0.3853,"url":"https://openalex.org/keywords/annexin-a6"},{"display_name":"S100A7","id":"s100a7","score":0.3278,"url":"https://openalex.org/keywords/s100a7"},{"display_name":"S100P","id":"s100p","score":0.3211,"url":"https://openalex.org/keywords/s100p"},{"display_name":"S100A10","id":"s100a10","score":0.3155,"url":"https://openalex.org/keywords/s100a10"},{"display_name":"S100A11","id":"s100a11","score":0.415,"url":"https://openalex.org/keywords/s100a11"},{"display_name":"S100A2","id":"s100a2","score":0.4518,"url":"https://openalex.org/keywords/s100a2"},{"display_name":"phospholipid-binding proteins","id":"phospholipid-binding-proteins","score":0.3292,"url":"https://openalex.org/keywords/phospholipid-binding-proteins"},{"display_name":"S100A13","id":"s100a13","score":0.5052,"url":"https://openalex.org/keywords/s100a13"},{"display_name":"psoriasin","id":"psoriasin","score":0.2569,"url":"https://openalex.org/keywords/psoriasin"},{"display_name":"calcyclin","id":"calcyclin","score":0.4845,"url":"https://openalex.org/keywords/calcyclin"},{"display_name":"S100A14","id":"s100a14","score":0.4573,"url":"https://openalex.org/keywords/s100a14"},{"display_name":"lipocortin","id":"lipocortin","score":0.4062,"url":"https://openalex.org/keywords/lipocortin"},{"display_name":"lipocortin I","id":"lipocortin-i","score":0.5602,"url":"https://openalex.org/keywords/lipocortin-i"}],"legacy_keywords":["S100 Proteins","Inflammation","Calcium Modulated Proteins","Neurodegeneration","Cancer Biomarkers","Traumatic Brain Injury","Innate Immunity","Glial Fibrillary Acidic Protein","Metastasis","Phagocytes"],"openalex_id":"https://openalex.org/T12030","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T12030","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12030","works_count":14961,"label":"S100 Proteins and Annexins","provider":"openalex","revision":"01a3e28291ac347a","taxonomy_revision":"f050b5d4780b1289","title":"S100 Proteins and Annexins","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36183297877387907","address_version":"morton4x16-v1","coordinates":[1,13,1312,12030],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}