{"cited_by_count":715097,"description":"This cluster of papers focuses on the pharmacology and toxicology of cholinesterase inhibitors, particularly acetylcholinesterase and butyrylcholinesterase, in the context of neurodegenerative diseases such as Alzheimer's. It explores the development of multi-target-directed ligands, novel drug therapies, and the implications for cognitive deficits. The research also delves into the structure, function, and regulation of cholinesterases, as well as their potential roles in neuroprotection and neurorestoration.","display_name":"Cholinesterase and Neurodegenerative Diseases","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T12023","wikipedia":"https://en.wikipedia.org/wiki/Cholinesterase_inhibitor"},"field_id":"27","id":"T12023","keywords":[{"display_name":"acetylcholinesterase","id":"acetylcholinesterase","score":0.2682,"url":"https://openalex.org/keywords/acetylcholinesterase"},{"display_name":"cholinesterase inhibitors","id":"cholinesterase-inhibitors","score":0.2946,"url":"https://openalex.org/keywords/cholinesterase-inhibitors"},{"display_name":"butyrylcholinesterase","id":"butyrylcholinesterase","score":0.404,"url":"https://openalex.org/keywords/butyrylcholinesterase"},{"display_name":"acetylcholinesterase inhibitors","id":"acetylcholinesterase-inhibitors","score":0.4136,"url":"https://openalex.org/keywords/acetylcholinesterase-inhibitors"},{"display_name":"acetylcholinesterase inhibition","id":"acetylcholinesterase-inhibition","score":0.2117,"url":"https://openalex.org/keywords/acetylcholinesterase-inhibition"},{"display_name":"cholinesterase","id":"cholinesterase","score":0.3175,"url":"https://openalex.org/keywords/cholinesterase"},{"display_name":"cholinesterase inhibition","id":"cholinesterase-inhibition","score":0.2659,"url":"https://openalex.org/keywords/cholinesterase-inhibition"},{"display_name":"donepezil","id":"donepezil","score":0.2009,"url":"https://openalex.org/keywords/donepezil"},{"display_name":"butyrylcholinesterase inhibition","id":"butyrylcholinesterase-inhibition","score":0.3977,"url":"https://openalex.org/keywords/butyrylcholinesterase-inhibition"},{"display_name":"tacrine","id":"tacrine","score":0.4526,"url":"https://openalex.org/keywords/tacrine"},{"display_name":"cholinesterase activity","id":"cholinesterase-activity","score":0.293,"url":"https://openalex.org/keywords/cholinesterase-activity"},{"display_name":"rivastigmine","id":"rivastigmine","score":0.2853,"url":"https://openalex.org/keywords/rivastigmine"},{"display_name":"butyrylcholinesterase inhibitors","id":"butyrylcholinesterase-inhibitors","score":0.8695,"url":"https://openalex.org/keywords/butyrylcholinesterase-inhibitors"},{"display_name":"anticholinesterase activity","id":"anticholinesterase-activity","score":0.2943,"url":"https://openalex.org/keywords/anticholinesterase-activity"},{"display_name":"peripheral anionic site","id":"peripheral-anionic-site","score":0.9139,"url":"https://openalex.org/keywords/peripheral-anionic-site"},{"display_name":"multi-target-directed ligands","id":"multitarget-directed-ligands","score":0.4743,"url":"https://openalex.org/keywords/multitarget-directed-ligands"},{"display_name":"acetylcholine hydrolysis","id":"acetylcholine-hydrolysis","score":0.6394,"url":"https://openalex.org/keywords/acetylcholine-hydrolysis"},{"display_name":"huperzine A","id":"huperzine-a","score":0.3316,"url":"https://openalex.org/keywords/huperzine-a"},{"display_name":"anti-Alzheimer agents","id":"anti-alzheimer-drugs","score":0.3983,"url":"https://openalex.org/keywords/anti-alzheimer-drugs"},{"display_name":"acetylcholinesterase reactivators","id":"acetylcholinesterase-reactivators","score":0.6954,"url":"https://openalex.org/keywords/acetylcholinesterase-reactivators"},{"display_name":"acetylcholinesterase reactivation","id":"acetylcholinesterase-reactivation","score":0.4516,"url":"https://openalex.org/keywords/acetylcholinesterase-reactivation"},{"display_name":"acetylthiocholine","id":"acetylthiocholine","score":0.45,"url":"https://openalex.org/keywords/acetylthiocholine"},{"display_name":"HI-6","id":"hi-6","score":0.3738,"url":"https://openalex.org/keywords/hi-6"},{"display_name":"tabun","id":"tabun","score":0.247,"url":"https://openalex.org/keywords/tabun"},{"display_name":"cholinesterase reactivation","id":"cholinesterase-reactivation","score":0.3249,"url":"https://openalex.org/keywords/cholinesterase-reactivation"}],"legacy_keywords":["Cholinesterase Inhibitors","Acetylcholinesterase","Butyrylcholinesterase","Alzheimer's Disease","Neurodegenerative Diseases","Multi-Target-Directed Ligands","Pharmacology","Toxicology","Drug Development","Cognitive Deficits"],"openalex_id":"https://openalex.org/T12023","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2736","url":"/topics/T12023","works_api_url":"https://api.openalex.org/works?filter=topics.id:T12023","works_count":40166,"label":"Cholinesterase and Neurodegenerative Diseases","provider":"openalex","revision":"10160ce9bab652db","taxonomy_revision":"f050b5d4780b1289","title":"Cholinesterase and Neurodegenerative Diseases","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249527347194282","address_version":"morton4x16-v1","coordinates":[4,27,2736,12023],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}